HAMNO Chemical Properties

Boiling point:

488.8±45.0 °C(Predicted)

Density 

1.392±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF:30.0(Max Conc. mg/mL);113.94(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);113.94(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:30):0.25(Max Conc. mg/mL);0.95(Max Conc. mM)

form 

A crystalline solid

pka

9.98±0.35(Predicted)

color 

Yellow to orange

HAMNO Usage And Synthesis

Uses

HAMNO, is a novel protein interaction inhibitor of replication protein A (RPA). It has shown to significantly inhibits colony formation when combined with etoposide.

Biological Activity

HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. HAMNO binds the N-terminal domain of RPA70 and inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO enhances DNA replication stress in cancer cells and slow tumor growth in vivo.

in vivo

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