HAMNO Chemical Properties

Boiling point:

488.8±45.0 °C(Predicted)

Density 

1.392±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF:30.0(Max Conc. mg/mL);113.94(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);113.94(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:30):0.25(Max Conc. mg/mL);0.95(Max Conc. mM)

form 

A crystalline solid

pka

9.98±0.35(Predicted)

color 

Yellow to orange

HAMNO Usage And Synthesis

Uses

HAMNO, is a novel protein interaction inhibitor of replication protein A (RPA). It has shown to significantly inhibits colony formation when combined with etoposide.

Biological Activity

HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. HAMNO binds the N-terminal domain of RPA70 and inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO enhances DNA replication stress in cancer cells and slow tumor growth in vivo.

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