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ChemicalBook >  Product Catalog >  Catalyst and Auxiliary >  polymer >  4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

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4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Basic information

Product Name:
4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Synonyms:
  • 4-[2-[2-[2-[2-(4-aminophenoxy)ethoxy]ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
  • Cereblon Ligand-Linker Conjugates 9
  • 4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • E3 Ligase Ligand-Linker Conjugates 2
  • 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-[2-(4-aminophenoxy)ethoxy]ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
  • Cereblon Ligand-Linker Conjugates 9(E3 Ligase Ligand-Linker Conjugates 2)
  • 4-[[2-[2-[2-[2-(4-Aminophenoxy)ethoxy]ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
  • 4-[12-(4-aminophenoxy)-4,7,10-trioxa-1-azadodecan-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS:
1818885-63-0
MF:
C27H32N4O8
MW:
540.57
Product Categories:
  • peg
Mol File:
1818885-63-0.mol
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4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties

Boiling point:
792.0±60.0 °C(Predicted)
Density 
1.363±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
10.74±0.40(Predicted)
form 
Solid
color 
Light yellow to yellow
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Safety Information

HS Code 
2933998090
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4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Usage And Synthesis

Description

Pomalidomide-PEG4-Ph-NH2 is comprised of the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. Pomalidomide-PEG4-Ph-NH2 is used in PROTAC technology as a E3 ligase ligand-linker conjugate that incorporates PEG technology that can be linked to a wide range of "warheads" that bind to proteins of interest.

4-((2-(2-(2-(2-(4-aminophenoxy)ethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneSupplier

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