Rucaparib Camsylate Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO:79.63(Max Conc. mg/mL);143.31(Max Conc. mM)

form 

Solid

color 

Light yellow to gray

Rucaparib Camsylate Usage And Synthesis

Uses

Rucaparib Camsylate is a novel DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1) inhibitor.

Definition

ChEBI: Rucaparib camsylate is a camphorsulfonate salt obtained by reaction of rucaparib with one molar equivalent of (1S,4R)-camphorsulfonic acid. It is an inhibitor of poly (ADP-ribose) polymerase and is used as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor. It is a camphorsulfonate salt and an azepinoindole. It contains a (S)-camphorsulfonate and a rucaparib(1+).

Biological Activity

Rucaparib is an inhibitor of the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It has been found to have anticancer activity in a number of cancers and has been approved for treatment of previously treated, BRCA-mutant ovarian cancer.

storage

Store at -20°C

Rucaparib Camsylate(1859053-21-6)Related Product Information

• DL-CAMPHORIC ANHYDRIDE
• (+/-)-EXO EXO-2 3-CAMPHANEDIOL
• (+)-10-CAMPHORSULFONIMINE
• (-)-(8,8-DICHLOROCAMPHORYLSULFONYL)OXAZIRIDINE
• (1S)-(+)-Camphor-10-sulphonic acid
• (1R)-(-)-10-Camphorsulfonic acid
• L(-)-10-Camphorsulfonyl chloride
• D-CAMPHOR
• (+)-(8,8-DICHLOROCAMPHORYLSULFONYL)OXAZIRIDINE
• (7,7-DIMETHYL-2-OXO-BICYCLO[2.2.1]HEPT-1-YL)-METHANESULFONYL CHLORIDE
• EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE
• EUROPIUM TRIS[3-(HEPTAFLUOROPROPYLHYDROXYMETHYLENE)-(+)-CAMPHORATE]
• PF-01367338
• (-)-3-(Trifluoroacetyl)camphor
• (2S)-Bornane-10,2-sultam
• [(1S)-ENDO]-(+)-3-BROMO-10-CAMPHORSULFONIC ACID MONOHYDRATE
• Rucaparib
• (1S)-(-)-Camphorsulfonylimine