Rucaparib Camsylate
Rucaparib Camsylate Basic information
- Product Name:
- Rucaparib Camsylate
- Synonyms:
-
- Rucaparib Camsylate
- 8‐Fluoro‐2‐(4‐methylaminomethyl‐phenyl)‐1,3,4,5‐tetrahydro‐azepino[5,4,3‐cd] indol‐6‐one (S)‐camphorsulfonate Salt
- Rucaparib Camphosulfonate
- Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one (1:1)
- 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H- azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7dimethyl-2-oxobicyclo [2.2.1] hept-1-yl) methanesulfonic acid salt
- Rucaparib monocamsylate
- 8-Fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate
- Asciminib Impurity 1
- CAS:
- 1859053-21-6
- MF:
- C29H34FN3O5S
- MW:
- 555.67
- Product Categories:
-
- api
- Mol File:
- 1859053-21-6.mol
Rucaparib Camsylate Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:79.63(Max Conc. mg/mL);143.31(Max Conc. mM)
- form
- Solid
- color
- Light yellow to gray
Rucaparib Camsylate Usage And Synthesis
Uses
Rucaparib Camsylate is a novel DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1) inhibitor.
Definition
ChEBI: Rucaparib camsylate is a camphorsulfonate salt obtained by reaction of rucaparib with one molar equivalent of (1S,4R)-camphorsulfonic acid. It is an inhibitor of poly (ADP-ribose) polymerase and is used as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor. It is a camphorsulfonate salt and an azepinoindole. It contains a (S)-camphorsulfonate and a rucaparib(1+).
Biological Activity
Rucaparib is an inhibitor of the DNA repair enzyme poly-ADP ribose polymerase-1 (PARP-1). It has been found to have anticancer activity in a number of cancers and has been approved for treatment of previously treated, BRCA-mutant ovarian cancer.
storage
Store at -20°C
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Rucaparib Camsylate(1859053-21-6)Related Product Information
- DL-CAMPHORIC ANHYDRIDE
- (+/-)-EXO EXO-2 3-CAMPHANEDIOL
- (+)-10-CAMPHORSULFONIMINE
- (-)-(8,8-DICHLOROCAMPHORYLSULFONYL)OXAZIRIDINE
- (1S)-(+)-Camphor-10-sulphonic acid
- (1R)-(-)-10-Camphorsulfonic acid
- L(-)-10-Camphorsulfonyl chloride
- D-CAMPHOR
- (+)-(8,8-DICHLOROCAMPHORYLSULFONYL)OXAZIRIDINE
- (7,7-DIMETHYL-2-OXO-BICYCLO[2.2.1]HEPT-1-YL)-METHANESULFONYL CHLORIDE
- EUROPIUM D-3-TRIFLUOROACETYLCAMPHORATE
- EUROPIUM TRIS[3-(HEPTAFLUOROPROPYLHYDROXYMETHYLENE)-(+)-CAMPHORATE]
- PF-01367338
- (-)-3-(Trifluoroacetyl)camphor
- (2S)-Bornane-10,2-sultam
- [(1S)-ENDO]-(+)-3-BROMO-10-CAMPHORSULFONIC ACID MONOHYDRATE
- Rucaparib
- (1S)-(-)-Camphorsulfonylimine