NH-(PEG3-Boc)2
NH-(PEG3-Boc)2 Basic information
- Product Name:
- NH-(PEG3-Boc)2
- Synonyms:
-
- NH-(PEG3-Boc)2
- NH-bis(PEG3-Boc)
- tert-butyl N-[2-[2-[2-[2-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethylamino]ethoxy]ethoxy]ethoxy]ethyl]carbamate
- NH-bis(PEG3-C2-NH-Boc)
- 5,8,11,17,20,23-Hexaoxa-2,14,26-triazaheptacosanedioic acid, 1,27-bis(1,1-dimethylethyl) ester
- CAS:
- 2055024-51-4
- MF:
- C26H53N3O10
- MW:
- 567.71
- Mol File:
- 2055024-51-4.mol
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NH-(PEG3-Boc)2 Chemical Properties
- Boiling point:
- 636.7±55.0 °C(Predicted)
- Density
- 1.072±0.06 g/cm3(Predicted)
- solubility
- Soluble in Water, DMSO, DCM, DMF
- pka
- 11.92±0.46(Predicted)
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NH-(PEG3-Boc)2 Usage And Synthesis
Description
NH-bis(PEG3-Boc) is a PEG molecule containing an amino (NH2) group with two Boc protected amines. Amino group is reactive with carboxylic acids, activated NHS esters, carbonyls. The protected amine can be deprotected under acidic conditions.
Uses
NH-bis(PEG3-C2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
NH-(PEG3-Boc)2Supplier
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