SPDP-PEG4-acid Chemical Properties

Boiling point:

677.3±55.0 °C(Predicted)

Density 

1.27±0.1 g/cm3(Predicted)

storage temp. 

2-8°C, stored under nitrogen

form 

Liquid

pka

4.28±0.10(Predicted)

color 

Colorless to light yellow

SPDP-PEG4-acid Usage And Synthesis

Description

SPDP-PEG4-acid is a PEG linker containing SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic properties of the PEG linkers increase compound solubility in aqueous media.

Uses

SPDP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

SPDP-PEG4-acid(581065-97-6)Related Product Information

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