FGF-401
FGF-401 Basic information
- Product Name:
- FGF-401
- Synonyms:
-
- N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
- N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-formyl-6-[(4-methyl-2-oxopiperazin-1-yl)methyl]-3,4-dihydro-2~{H}-1,8-naphthyridine-1-carboxamide
- Roblitinib（FGF-401）
- FGF 401;FGF-401
- 8-naphthyridine-1(2H)-carboxamide
- 0997
- N-[5-Cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide
- Roblitinib
- CAS:
- 1708971-55-4
- MF:
- C25H30N8O4
- MW:
- 506.56
- Product Categories:
-
- API
- Mol File:
- 1708971-55-4.mol
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FGF-401 Chemical Properties
- Boiling point:
- 852.1±65.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:5.4(Max Conc. mg/mL);10.66(Max Conc. mM)
Chloroform:30.0(Max Conc. mg/mL);59.22(Max Conc. mM) - form
- A crystalline solid
- pka
- 11.40±0.20(Predicted)
- color
- White to off-white
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FGF-401 Usage And Synthesis
Description
FGF401 is an inhibitor of FGF receptor 4 (FGFR4; IC50 = 1.9 nM). It inhibits proliferation of Huh7 carcinoma cells with an IC50 value of 12 nM. FGF401 induces bile acid synthesis in dogs, increasing plasma and fecal levels of bile acids when administered at a dose of 45 mg/kg per day for four weeks. It also decreases serum cholesterol when administered at doses ranging from 5 to 45 mg/kg per day.
FGF-401Supplier
Shanghai Synchem Pharma Co., ltd Gold
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com
Shanghai Dongyang Biotechnology Co., Ltd. Gold
- Tel
- 0512-0512-13601744364 13601744364
- chemsharker@126.com
Kaixin Chemical (Hong Kong) Limited Gold
- Tel
- 010-88886666-01 13112345678
- loyson@tcypharm.com
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Jia Xing Isenchem Co.,Ltd
- Tel
- 0573-85285100 18627885956
- isenchem@163.com