1-(2-THIAZOLYLAZO)-2-NAPHTHOL Chemical Properties

Melting point:

138-139 °C

Boiling point:

464.8±47.0 °C(Predicted)

Density 

1.40

storage temp. 

2-8°C

solubility 

methanol: 10 mg/mL, clear

pka

8.71±0.50(Predicted)

form 

solid

color 

Red or orange

BRN 

223783

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

CAS DataBase Reference

1147-56-4(CAS DataBase Reference)

EPA Substance Registry System

2-Naphthalenol, 1-(2-thiazolylazo)- (1147-56-4)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

22-24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

2927.00.5000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-(2-THIAZOLYLAZO)-2-NAPHTHOL Usage And Synthesis

Description

ERGi-USU (1147-56-4) selectively inhibits the growth of ERG-positive VCaP prostate cancer cells, COLO320 colon cancer cells, KG-1 and MOLT-4 leukemia cells with minimal effect on ERG-negative cells or normal prostate or endothelial cells (IC50 = 169 nM for cell growth and 315 nM for ERG protein in VCaP cells). It selectively inhibits the kinase RIOK2 (Kd = 200 nM) causing disruption of ribosomal biogenesis and ribosomal stress.

Uses

1-(2-Thiazolylazo)-2-naphthol is a high affinity Rio Kinase 2 (RIOK2) inhibitor (Kd = 200 nM). Exhibits >6-fold selectivity for RIOK2 over a panel of 456 kinases. Inhibits ERG protein and potently inhibits growth of ERG-positive VCaP prostate cancer cells in vitro (IC50 = 169 nM) but not ERG-negative cell lines. Also inhibits growth of VCaP xenografts in mice.

storage

Store at +4°C

References

1) Mohamed et al. (2018), Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth; Cancer Res. 78 3659

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