(R)-(+)-PROPRANOLOL
(R)-(+)-PROPRANOLOL Basic information
- Product Name:
- (R)-(+)-PROPRANOLOL
- Synonyms:
-
- R-PROPANOLOL
- R-(+)-PROPANOLOL HCL
- 2R-(+)-Propanolol hydrochloride≥ 95% (GCMS)
- (R)-(+)-Propanolol hydrochloride for synthesis
- 2R-(+)-PROPANOLOL HYDROCHLORIDE
- 2-Propanol, 1-(1-methylethyl)amino-3-(1-naphthalenyloxy)-, hydrochloride, (2R)-
- (+)-Anapriline
- 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-, hydrochloride, (+)- (8CI)
- CAS:
- 13071-11-9
- MF:
- C16H21NO2.ClH
- MW:
- 295.81
- EINECS:
- 235-961-7
- Product Categories:
-
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 13071-11-9.mol
(R)-(+)-PROPRANOLOL Chemical Properties
- Melting point:
- 196-198 °C(lit.)
- storage temp.
- Store below +30°C.
- solubility
- ethanol: 10 mg/mL
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Soluble to 100 mM in water
- BRN
- 5780490
- CAS DataBase Reference
- 13071-11-9(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
(R)-(+)-PROPRANOLOL Usage And Synthesis
Description
(R)-Propranolol hydrochloride is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist with high affinity for β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.
Physical properties
(R)-Propranolol's solubility:ethanol: 10 mg/mLDMSO: <14.5 mg/mLH2O: 50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)
Uses
less active enantiomer
Uses
The R-enantiomer of Propranolol (P831800). β?Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
Biochem/physiol Actions
Less active enantiomer of propranolol.
Mechanism of action
Pronolol hydrochloride is a non-selective beta-receptor blocker that blocks beta receptors in the myocardium and has antagonistic effects on beta1 and beta2 receptors. Slow down the heart rate, inhibit cardiac contractility and conduction, reduce circulating blood volume, and reduce myocardial oxygen consumption.
storage
Store at RT
Purification Methods
The hydrochloride is recrystallised from n-PrOH or Me2CO. It is soluble in H2O and EtOH but is insoluble in Et2O, *C6H6 or EtOAc. The racemate has m 163-164o, and the free base recrystallises from cyclohexane with m 96o. [Howe & Shanks Nature 210 1336 1966.] The S-isomer (below) is the physiologically active isomer.
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(R)-(+)-PROPRANOLOL(13071-11-9)Related Product Information
- (R)-4-Hydroxy Propranolol Hydrochloride,(S)-4-Hydroxy Propranolol Hydrochloride
- (R)-(+)-PROPRANOLOL
- PROPRANOLOL H+D409CL USP,DL-Propranolol hydrochloride, (±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride
- Propranolol Hydrochloride for pharmaceutical raw materials
- L-(-)-Propranolol hydrochloride,l-Propranolol chlorhydrate,l-Propranolol hydrochloride
- Propanolol
- 4-Hydroxy Propranolol b-D-Glucuronide,4-Hydroxy Propranolol -D-Glucuronide
- rac Propranolol -D-Glucuronide Sodium Salt,propranolol glucuronide,rac Propranolol b-D-Glucuronide Sodium Salt
- (S)-4-Hydroxy Propranolol
- (+/-)-4Hydroxy Propranolol-d7 Sulfate
- 5-Hydroxy Propranolol-d5
- rac 7-Hydroxy Propranolol
- O-isovaleryl propranolol
- (2S)-Propranolol,l-Propranolol
- Propranolol hydrochloride for performance test
- (R)-4-Hydroxy Propranolol
- 4-HYDROXY PROPRANOLOL-D5 GLUCURONIDE
- rac 4-Hydroxy Propranolol-d7 -D-Glucuronide