inS3-54A18
inS3-54A18 Basic information
- Product Name:
- inS3-54A18
- Synonyms:
-
- inS3-54A18
- 2H-Pyrrol-2-one, 3-[(4-chlorophenyl)methylene]-1,3-dihydro-1-(4-hydroxyphenyl)-5-phenyl-
- 3-(4-Chlorobenzylidene)-1-(4-hydroxyphenyl)-5-phenyl-1,3-dihydro-2H-pyrrol-2-one
- inS3-54A18,Inhibitor,inS-3-54A18,inS3 54A18,inS354A18,inhibit,STAT
- CID 1920398
- inS3-54A18, 10 mM in DMSO
- CAS:
- 328998-53-4
- MF:
- C23H16ClNO2
- MW:
- 373.83
- Mol File:
- 328998-53-4.mol
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inS3-54A18 Chemical Properties
- Boiling point:
- 630.5±55.0 °C(Predicted)
- Density
- 1.363±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 150 mg/mL (401.25 mM)
- form
- Solid
- pka
- 10.05±0.30(Predicted)
- color
- Yellow to orange
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inS3-54A18 Usage And Synthesis
Uses
inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.
in vivo
inS3-54A18 (200?mg/kg, p.o.) inhibits tumor growth, metastasis and expression of STAT3 target genes in a mouse xenograft model of A549 cells[1].
IC 50
STAT3
References
[1] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92. DOI:10.1038/onc.2015.215
[2] Huang W, et al. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 2016 Feb 11;35(6):783-92
inS3-54A18Supplier
MedChemexpress LLC
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Shanghai YuanYe Biotechnology Co., Ltd.
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Shanghai Rechem science Co., Ltd.
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- 021-31433387 15618786686
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Amadis Chemical Company Limited
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- 571-89925085
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Beijing Jin Ming Biotechnology Co., Ltd.
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- 010-60605840 18892239720
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