DICHLORISONE ACETATE Chemical Properties

Melting point:

246-253 °C (decomp)

Boiling point:

596.2±50.0 °C(Predicted)

alpha 

D25 +162° (dioxane)

Density 

1.34±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 4.35 mg/mL (9.55 mM); Water: < 0.1 mg/mL (insoluble)

pka

11.94±0.70(Predicted)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

DICHLORISONE ACETATE Usage And Synthesis

Originator

Diloderm ,Schering,US,1960

Uses

antipruretic

Definition

ChEBI: Dichlorisone is a corticosteroid hormone.

Manufacturing Process

A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21- acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture is stirred for 2 hours and poured into ice water. The crude product is filtered and washed with water to give 1.12 g of solid material, which is recrystallized from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4- pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).

brand name

Diloderm (Schering).

Therapeutic Function

Antipruritic, Antihistaminic, Appetite stimulant

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