RO-31-8425 Chemical Properties

Boiling point:

736.1±60.0 °C(Predicted)

Density 

1.43±0.1 g/cm3(Predicted)

storage temp. 

0-6°C

solubility 

DMSO: 10mg/mL

form 

Red to orange-red solid

pka

7.91±0.60(Predicted)

color 

red to orange-red

InChI

1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)

InChIKey

QQKKPWJFHBFCTH-UHFFFAOYSA-N

SMILES

[n]21c3c(c(c2CC(CC1)CN)C4=C(C(=O)NC4=O)c5c6c([n](c5)C)cccc6)cccc3

Safety Information

WGK Germany 

WGK 1

HS Code 

2925199590

Storage Class

11 - Combustible Solids

RO-31-8425 Usage And Synthesis

Uses

Bisindolylmaleimide X is a selective inhibitor of PKC, also inhibits Cdk2 and GSK-3β.

Biological Activity

Cell permeable: yes', 'Primary Target
PKC', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 15 nM for r at brain PKC; 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε

RO-31-8425(131848-97-0)Related Product Information

• RO-31-8425,RO 31-8425 HYDROCHLORIDE,RO 31 8425 HCL
• RO-32-0432
• RO-31-8425