DULCIN Chemical Properties

Melting point:

160-161℃

Boiling point:

313.03°C (rough estimate)

Density 

1.199

refractive index 

1.5373 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

color 

White to Off-White

Water Solubility 

1.21g/L(21 ºC)

λmax

289nm(EtOH)(lit.)

Merck 

14,3464

LogP

1.005 (est)

CAS DataBase Reference

150-69-6

IARC

3 (Vol. 12, Sup 7) 1987

EPA Substance Registry System

Dulcin (150-69-6)

Safety Information

Hazard Codes 

Xi

RTECS 

YT2275000

Hazard Note 

Irritant

HS Code 

2924190090

Hazardous Substances Data

150-69-6(Hazardous Substances Data)

DULCIN Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

Dulcin is a non-nutritive sweetener. Dulcin is a sweet analgesic for use in medical procedures or treatments.

Definition

ChEBI: Dulcin is a member of ureas.

Production Methods

4-Ethoxyphenylurea, dulcin, is produced from the addition of potassium cyanate to p-phenetidine hydrochloride in aqueous solution at room temperature or from mixing urea and p-phenetidine hydrochloride to a mixture of hydrochloric acid and glacial acetic acid.

General Description

White crystals.

Air & Water Reactions

Partially decomposes on heating in water; hydrolyzes in 0.1 N acetic acid. Slightly water soluble .

Reactivity Profile

DULCIN is an example of an amide. Amides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Safety Profile

Human poison by ingestion. Moderately toxic experimentally by ingestion. Human systemic effects by ingestion: somnolence, hallucinations, distorted perceptions, and changes in motor activity. In adults 20 to 40 g produces dizziness, nausea, methemoglobinemia, cyanosis, and hypotension. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.

DULCIN(150-69-6)Related Product Information

• DULCIN
• Phenylurea
• Celiprolol
• Lufenuron
• NBP 584
• 1-(4-ETHOXYPHENYL)PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE
• talinolol
• dulcin saponin
• AURORA 4986
• [4-(propan-2-yloxy)phenyl]urea
• AURORA 11864
• AURORA 4981
• AURORA 7437
• N1-(2,6-DICHLORO-3-PYRIDYL)-2-([4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-5-OXO-4,5-DIHYDRO-1H-1,2,4-TRIAZOL-3-YL]SULFANYL)ACETAMIDE
• AURORA 11901
• AURORA 6612
• SALOR-INT L308773-1EA
• AURORA 5617