4'-Chloroacetoacetanilide Chemical Properties

Melting point:

131-134 °C (lit.)

Boiling point:

303°C (rough estimate)

Density 

1.44 g/cm3 (20℃)

vapor density 

7.31

refractive index 

1.5388 (estimate)

Flash point:

350°F(COC)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

acetone: soluble25mg/mL, clear, colorless to light yellow

form 

Crystalline Powder

pka

11.00±0.46(Predicted)

color 

Off-white to beige

CAS DataBase Reference

101-92-8(CAS DataBase Reference)

NIST Chemistry Reference

Butanamide, N-(4-chlorophenyl)-3-oxo-(101-92-8)

EPA Substance Registry System

Butanamide, N-(4-chlorophenyl)-3-oxo- (101-92-8)

Safety Information

Safety Statements 

24/25

WGK Germany 

1

RTECS 

AK4375000

HS Code 

29242990

Hazardous Substances Data

101-92-8(Hazardous Substances Data)

Toxicity

ipr-mus LDLo 500 mg/kg CBCCT* 4,225,52

MSDS

• Language:English Provider:4'-Chloroacetoacetanilide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

4'-Chloroacetoacetanilide Usage And Synthesis

Chemical Properties

off-white to beige crystalline powder

Uses

4′-Chloroacetoacetanilide was used in recombinant androgen receptor competitive binding assay for analysis of natural, synthetic and environmental chemicals.

Definition

ChEBI: P-Chloroacetoacetanilide is an anilide.

General Description

4′-Chloroacetoacetanilide was trilithiated with lithium diisopropylamide and condensed with several aromatic esters, followed by neutralization, separate acid cyclization and rearrangements to yield 4-anilino-6-aryl-2H-pyran-2-ones. It undergoes three-component reaction with a mixture of aromatic aldehyde and 5-aminotetrazole to form N,7-diaryl-5-methyl-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxamide.

Safety Profile

Moderately toxic by intraperitonealroute. Combustible whenexposed to heat or flame. Dangerous: see ANILINE andCYANIDE. Can react vigorously with oxidizing materials.To fight fire, use water, foam, CO2, water mist, drychemical. When heated to decompo

4'-Chloroacetoacetanilide(101-92-8)Related Product Information

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