KASUGAMYCIN Chemical Properties

Boiling point:

507.24°C (rough estimate)

Density 

1.2554 (rough estimate)

refractive index 

1.5700 (estimate)

solubility 

Aqueous Base (Slightly), Water (Slightly)

form 

Solid

pka

-0.62±0.41(Predicted)

color 

Pale Yellow to Pale Beige

InChIKey

PVTHJAPFENJVNC-RKODIXKRNA-N

SMILES

O=C(C(=N)N[C@H]1C[C@H](N)[C@@H](O[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H]2O)O[C@@H]1C)O |&1:5,7,9,11,12,14,16,18,20,23,r|

CAS DataBase Reference

6980-18-3

EPA Substance Registry System

Kasugamycin (6980-18-3)

Safety Information

Hazardous Substances Data

6980-18-3(Hazardous Substances Data)

KASUGAMYCIN Usage And Synthesis

Description

Trade names: “Kasugamin,” “Kasumin” Patent: JP 42006818; BE 657659: GB 1094566. Systemic fungicide and bactericide with protective and curative action. Controls rice blast caused by Pyricularia oryzae and other rice diseases, such as bacterial grain rot, bacterial seedling blight, and bacterial brown stripe caused by Pseudomonas spp. (15). Effective on other plant diseases, e.g., leaf mold and bacterial canker in tomatoes, bean halo blight, scab on apples, Cercospora spp. leaf spot on sugar beet, and bacterial soft rot on potatoes.

Uses

Kasugamycin is an antibiotic aminoglycoside that inhibits protein synthesis.

Definition

ChEBI: An amino cyclitol glycoside that is isolated from Streptomyces kasugaensis and exhibits antibiotic and fungicidal properties.

General Description

Kasugamycin was found in the culture broth of Streptomyces kasugaensis by Umezawa et al. in 1965. It has an aminocyclitol structure and shows strong activity against phytopathogenic fungi, especially Pericularia oryzae, the pathogen causing rice blast. This drug also shows activity against Pseudomonas, and its toxicity is very low; no mice died following intravenous injection of doses as high as two grams per kilogram. Kasugamycin has been used to protect rice plants against rice blast and for animal infections.

Toxicity evaluation

Nonphytotoxic to rice, tomatoes, sugar beet, potatoes, and other vegetables, but slightly toxic to peas, beans, grapes, citrus, and apples.

KASUGAMYCIN(6980-18-3)Related Product Information

• KANAMYCIN B SULFATE
• Chlorothalonil
• Thiodiazole copper
• Prochloraz manganese
• Potassium Phosphate Monobasic
• Ethylicin
• Gelatin
• Cupric hydroxide
• Monensin
• Bekanamycin
• D-chiro-inositol
• Kasugamycin hydrochloride
• kasugamycin hemisulfate
• Kasugamycin W.P.
• Kasugamycin+Tricycloazole,W.P.
• Kasugamycin+Sulfur,W.P.
• Kasugamycin sulfate
• KASUGAMYCIN+TRICYCLAZOLE