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PROTOVERATRINE B

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PROTOVERATRINE B Basic information

Product Name:
PROTOVERATRINE B
Synonyms:
  • [3beta(2R,3R),4alpha,6alpha,7alpha,15alpha(R),16beta]-4,9-epoxycevane-3,4,6,7,14,15,16,20-octol 6,7-diacetate 3-(2,3-dihydroxy-2-methylbutyrate) 15-(2-methylbutyrate)
  • PROTOVERATRINE B (RG)
  • PROTOVERATRINE B
  • NEOPROTOVERATRINE
  • 4-beta,6-alpha,7-alpha,14,15-alpha-16-beta,20-octol,4,9-epoxy-cevane-3-bet
  • 4α,9-Epoxycevane-3β,4β,6α,7α,14,15α,16β,20-octol 6,7-diacetate 3-[(2R,3R)-2,3-dihydroxy-2-methylbutanoate]15-[(R)-2-methylbutanoate]
  • PROTOVERATRINE A (RG)(CALL)
  • 6,7-diacetate3-(threo-(+)-2,3-dihydroxy-2-methylbutyrate)15-((-)-2-methylbut
CAS:
124-97-0
MF:
C41H63NO15
MW:
809.94
EINECS:
204-719-2
Product Categories:
  • Miscellaneous Natural Products
Mol File:
124-97-0.mol
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PROTOVERATRINE B Chemical Properties

Melting point:
268-270°C
alpha 
D25 -37° (pyridine); D25 -3.5° (chloroform)
Boiling point:
755.18°C (rough estimate)
Density 
1.1826 (rough estimate)
refractive index 
1.6220 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
pka
10.73±0.70(Predicted)
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Safety Information

Safety Statements 
22-24/25
RIDADR 
1544
WGK Germany 
3
RTECS 
FL5750000
HazardClass 
6.1(a)
PackingGroup 
II
Toxicity
LD50 s.c. in male mice: 0.21 mg/kg (Tanaka)

MSDS

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PROTOVERATRINE B Usage And Synthesis

Description

Also present in Veratrum album, this closely allied alkaloid may be separated from the preceding base by chromatography. It also yields colourless crystals from EtOH and is laevorotatory with [α]29D&o - 39.8° (pyridine) or - 3.5° (CHCI3). In this case, alkaline hydrolysis gives protoverine, two moles of acetic acid, one mole of (-)-2-methylbutyric acid and one mole of 2: 3-dihydroxy-2- methylbutyric acid. It may be distinguished from protoveratrine A by giving a green colour with H2S04. It also forms a complex with maleic acid having m.p. 222.2°C; [α]29D&o - 27.3°.

References

Stoll, Seebeck., Helv. Chim. Acta., 36,718 (1953)

PROTOVERATRINE BSupplier

Meryer (Shanghai) Chemical Technology Co., Ltd.
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021-61259108 18621169109
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market03@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Shaanxi Dideu Medichem Co. Ltd
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+86-029-81138252 +86-18789408387
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1057@dideu.com
Shaanxi Dideu Medichem Co. Ltd
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029-61856358 15229202216
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1020@dideu.com