2-Bromo-3-fluorophenol Chemical Properties

Boiling point:

123 °C(Press: 50 Torr)

Density 

1.764±0.06 g/cm3(Predicted)

refractive index 

1.56

storage temp. 

Inert atmosphere,Room Temperature

form 

clear liquid

pka

7.43±0.10(Predicted)

color 

Colorless to Light yellow to Light orange

CAS DataBase Reference

443-81-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

T,Xn

Risk Statements 

20/21/22-36/37/38-22

Safety Statements 

26-36/37/39

RIDADR 

UN1760

HazardClass 

8

HS Code 

2908190090

2-Bromo-3-fluorophenol Usage And Synthesis

Description

2-Bromo-3-fluorophenol is a chemical intermediate commonly used in organic synthesis and laboratory research. It can be used to prepare monofluorophenol.

Chemical Properties

light yellow liquid

Uses

2-Bromo-3-fluorophenol has been used as a reactant in the preparation of diaryl ethers.

Synthesis

1. 120 mL of isopropanol, 200 mL of 6M hydrochloric acid and 81 g (345 mmol) of 1-(methoxymethoxy)-2-bromo-3-fluorophenol were mixed and stirred for 2.5 hours at room temperature. 2. Upon completion of the reaction, the reaction mixture was partitioned. 400 ml of methyl tert-butyl ether and 120 ml of 5N sodium hydroxide were added. 3. The organic phase was separated, washed with saturated aqueous sodium chloride solution and then dried over anhydrous sodium sulfate. 4. The dried organic phase is concentrated under pressure to give an oily residue. 5. purify the residue by silica gel column chromatography and collect the fraction containing 2-bromo-3-fluorophenol. 6. Concentrate the combined fractions under pressure to give 55.1 g (84% yield) of the target compound 2-bromo-3-fluorophenol as a colorless oil.

References

[1] Patent: EP1204660, 2004, B1. Location in patent: Page 19

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