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2-Hydroxyisobutyric acid

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2-Hydroxyisobutyric acid Basic information

Product Name:
2-Hydroxyisobutyric acid
Synonyms:
  • Propanoic acid, 2-methyl-2-hydroxy-
  • A-HYDROXY-ISO-BUTYRIC ACID
  • 2-MethyllaCLic Acid
  • alpha-Hydroxyisobutyric acid 98%
  • 2-Hydroxyisobutyric acid for synthesis
  • RARECHEM AL BO 0199
  • alpha-Hydroxyisobutanoic acid
  • Hydroxydimethylacetic acid
CAS:
594-61-6
MF:
C4H8O3
MW:
104.1
EINECS:
209-848-8
Product Categories:
  • Carboxylic Acids
  • Chemical Synthesis
  • FINE Chemical & INTERMEDIATES
  • Organic acids
  • Building Blocks
  • Organic Building Blocks
  • C1 to C5
  • Carbonyl Compounds
  • bc0001
Mol File:
594-61-6.mol
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2-Hydroxyisobutyric acid Chemical Properties

Melting point:
76-80 °C(lit.)
Boiling point:
84 °C1.5 mm Hg(lit.)
Density 
11412
refractive index 
1.4761 (estimate)
Flash point:
114°C/12mm
storage temp. 
Sealed in dry,Room Temperature
solubility 
water: soluble10%, clear to very slightly hazy, colorless
pka
pK1:3.717 (25°C,μ=0.1)
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water, ether, alcohol, methanol and hot benzene.
BRN 
1744739
LogP
-0.360
CAS DataBase Reference
594-61-6(CAS DataBase Reference)
NIST Chemistry Reference
Propanoic acid, 2-hydroxy-2-methyl-(594-61-6)
EPA Substance Registry System
Propanoic acid, 2-hydroxy-2-methyl- (594-61-6)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
37/38-41-36/37/38
Safety Statements 
26-39-25-36
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29181980

MSDS

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2-Hydroxyisobutyric acid Usage And Synthesis

Chemical Properties

white to off-white needle-like crystals or

Uses

2-Hydroxyisobutyric acid is used as an electrolyte in the separation of the metal ions by on-line cyclic voltammetry. It is also used as a building block for the synthesis of polymers. Its conjugate base, 2-hydroxybutyrate is utilized to catabolize L-threonine as well as synthesize glutathione. Further, it is used as an indicator for the early detection insulin resistance in non-diabetic subjects.

Uses

α-Hydroxyisobutyric acid was used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.

Uses

2-Hydroxyisobutyric acid is used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.

Definition

ChEBI: A 2-hydroxy monocarboxylic acid that is isobutyric acid bearing a hydroxy substituent at position 2. It is a metabolite of methyl tertiary-butyl ether.

Synthesis Reference(s)

The Journal of Organic Chemistry, 23, p. 1488, 1958 DOI: 10.1021/jo01104a022

General Description

α-Hydroxyisobutyric acid (2-hydroxyisobutyric acid) is the building block for polymer synthesis. It forms complexes with Eu(III) and has been studied by time resolved fluorescence spectroscopy.

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