2-Hydroxyisobutyric acid Chemical Properties

Melting point:

76-80 °C(lit.)

Boiling point:

84 °C1.5 mm Hg(lit.)

Density 

11412

refractive index 

1.4761 (estimate)

Flash point:

114°C/12mm

storage temp. 

Sealed in dry,Room Temperature

solubility 

water: soluble10%, clear to very slightly hazy, colorless

pka

pK1:3.717 (25°C,μ=0.1)

form 

Solid

color 

White to Off-White

Water Solubility 

Soluble in water, ether, alcohol, methanol and hot benzene.

BRN 

1744739

LogP

-0.360

CAS DataBase Reference

594-61-6(CAS DataBase Reference)

NIST Chemistry Reference

Propanoic acid, 2-hydroxy-2-methyl-(594-61-6)

EPA Substance Registry System

Propanoic acid, 2-hydroxy-2-methyl- (594-61-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

37/38-41-36/37/38

Safety Statements 

26-39-25-36

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29181980

MSDS

• Language:English Provider:2-Methyllactic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Hydroxyisobutyric acid Usage And Synthesis

Chemical Properties

white to off-white needle-like crystals or

Uses

2-Hydroxyisobutyric acid is used as an electrolyte in the separation of the metal ions by on-line cyclic voltammetry. It is also used as a building block for the synthesis of polymers. Its conjugate base, 2-hydroxybutyrate is utilized to catabolize L-threonine as well as synthesize glutathione. Further, it is used as an indicator for the early detection insulin resistance in non-diabetic subjects.

Uses

α-Hydroxyisobutyric acid was used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.

Uses

2-Hydroxyisobutyric acid is used as background electrolyte for separation and detection of the metal ions by on-line cyclic voltammetry.

Definition

ChEBI: A 2-hydroxy monocarboxylic acid that is isobutyric acid bearing a hydroxy substituent at position 2. It is a metabolite of methyl tertiary-butyl ether.

Synthesis Reference(s)

The Journal of Organic Chemistry, 23, p. 1488, 1958 DOI: 10.1021/jo01104a022

General Description

α-Hydroxyisobutyric acid (2-hydroxyisobutyric acid) is the building block for polymer synthesis. It forms complexes with Eu(III) and has been studied by time resolved fluorescence spectroscopy.

2-Hydroxyisobutyric acid(594-61-6)Related Product Information

• Lactic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Isobutyric acid
• 3-Hydroxybenzaldehyde
• 2-(4-Chlorophenoxy)-2-methylpropionic acid
• 3-(4-Hydroxyphenyl)propionic acid
• CHLOROPHOSPHONAZO III
• Folic acid
• Methyl (R)-(-)-3-hydroxybutyrate
• Hydroxy silicone oil
• Dimethyl 2,2'-azobis(2-methylpropionate)
• Sucrose acetate isobutyrate
• 2,2-Bis(hydroxymethyl)propionic acid
• L(+)-Lactic acid
• 2,3-Dibromopropionic acid
• Methyl 2-bromo-2-methylpropionate
• Citric acid
• Ascoric Acid