Phenetidine Chemical Properties

Melting point:

2-5 °C(lit.)

Boiling point:

250 °C(lit.)

Density 

1.065 g/mL at 25 °C(lit.)

vapor pressure 

2.93Pa at 25℃

refractive index 

n20/D 1.559(lit.)

Flash point:

240 °F

storage temp. 

2-8°C

solubility 

20g/l

form 

A liquid

pka

5.2(at 28℃)

color 

Clear Yellow

PH

8 (1g/l, H2O, 20℃)

Water Solubility 

practically insoluble

Sensitive 

Air Sensitive

Merck 

14,7228

BRN 

606666

Dielectric constant

7.3（21℃）

Stability:

Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents.

InChIKey

IMPPGHMHELILKG-UHFFFAOYSA-N

CAS DataBase Reference

156-43-4(CAS DataBase Reference)

NIST Chemistry Reference

4-Ethoxyaniline(156-43-4)

EPA Substance Registry System

p-Phenetidine (156-43-4)

Safety Information

Hazard Codes 

T,Xi,Xn

Risk Statements 

23/24/25-33-68-43-36-20/21/22

Safety Statements 

28-36/37-45-46

RIDADR 

UN 2311 6.1/PG 3

WGK Germany 

1

RTECS 

SI6465500

F 

8-10

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29222200

Toxicity

LD50 orl-rat: 580 mg/kg GISAAA 35(8),28,70

MSDS

• Language:English Provider:4-Ethoxyaniline
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Phenetidine Usage And Synthesis

Chemical Properties

colourless liquid

Uses

A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.

Definition

ChEBI: An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 27, p. 347, 1984 DOI: 10.1021/jm00369a019

General Description

Colorless to dark red liquid.

Air & Water Reactions

Very sensitive to exposure to air and light. Turns red to brown on exposure to light and air. . Slightly soluble in water.

Reactivity Profile

Phenetidine reacts vigorously with powerful oxidizers.

Fire Hazard

Phenetidine is combustible.

Safety Profile

Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Caution: It can be absorbed through the skin. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Phenetidine(156-43-4)Related Product Information

• Sulfanilic acid
• Ethoxyethyne
• 4-(Trifluoromethoxy)aniline
• 4-Aminophenylacetic acid
• Ethoxyamine hydrochloride
• 4-Ethylaniline
• 4-Amino-benzenesulfonic acid monosodium salt
• Sulfanilamide
• Ethoxyquin
• Ethoxymethylenemalononitrile
• DIETHOXYMETHANE
• m-Anisidine
• 4'-Ethoxyacetophenone
• 4-Aminoveratrole
• 4-Aminobenzaldehyde
• p-Anisidine
• 4-Ethoxyphenol
• 4-Aminobenzoic acid