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Phenetidine

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Phenetidine Basic information

Product Name:
Phenetidine
Synonyms:
  • Amino-phenyl ethyl ether
  • Aniline, p-ethoxy-
  • Benzenam
  • Benzenamine, 4-ethoxy-
  • benzenamine,4-ethoxy-
  • cp5685
  • p-Aminofenetol
  • p-Aminophenetole
CAS:
156-43-4
MF:
C8H11NO
MW:
137.18
EINECS:
205-855-5
Product Categories:
  • Amines
  • Aromatics
  • INORGANIC & ORGANIC CHEMICALS
  • Phenetole
  • Metabolites & Impurities
  • Mutagenesis Research Chemicals
  • Anilines (Building Blocks for Liquid Crystals)
  • Building Blocks for Liquid Crystals
  • Functional Materials
  • Amines, Aromatics, Metabolites & Impurities, Mutagenesis Research Chemicals
Mol File:
156-43-4.mol
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Phenetidine Chemical Properties

Melting point:
2-5 °C(lit.)
Boiling point:
250 °C(lit.)
Density 
1.065 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.559(lit.)
Flash point:
240 °F
storage temp. 
2-8°C
solubility 
20g/l
form 
A liquid
pka
5.2(at 28℃)
PH
8 (1g/l, H2O, 20℃)
Water Solubility 
practically insoluble
Sensitive 
Air Sensitive
Merck 
14,7228
BRN 
606666
Stability:
Stability Stable, but light and air sensitive. Combustible. Incompatible with strong oxidizing agents.
InChIKey
IMPPGHMHELILKG-UHFFFAOYSA-N
CAS DataBase Reference
156-43-4(CAS DataBase Reference)
NIST Chemistry Reference
4-Ethoxyaniline(156-43-4)
EPA Substance Registry System
p-Phenetidine (156-43-4)
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Safety Information

Hazard Codes 
T,Xi,Xn
Risk Statements 
23/24/25-33-68-43-36-20/21/22
Safety Statements 
28-36/37-45-46
RIDADR 
UN 2311 6.1/PG 3
WGK Germany 
1
RTECS 
SI6465500
8-10
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29222200
Toxicity
LD50 orl-rat: 580 mg/kg GISAAA 35(8),28,70

MSDS

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Phenetidine Usage And Synthesis

Chemical Properties

colourless liquid

Uses

A toxic metabolite of Phenacetin (P294580) which exhibits high renal toxicity. p-Phenetidine also reduced COX-1 and COX-2 expression in neutrophils.

Definition

ChEBI: An aromatic ether that is aniline in which the hydrogen at position 4 is replaced by an ethoxy group. It is a hydrolysis metabolite of phenacetin.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 27, p. 347, 1984 DOI: 10.1021/jm00369a019

General Description

Colorless to dark red liquid.

Air & Water Reactions

Very sensitive to exposure to air and light. Turns red to brown on exposure to light and air. . Slightly soluble in water.

Reactivity Profile

Phenetidine reacts vigorously with powerful oxidizers.

Fire Hazard

Phenetidine is combustible.

Safety Profile

Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Caution: It can be absorbed through the skin. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

PhenetidineSupplier

J & K SCIENTIFIC LTD.
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Alfa Aesar
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400-610-6006; 021-67582000
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021-67121386 / 800-988-0390
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