D-Lysergic Acid Methyl Ester Chemical Properties

Melting point:

164-166 °C(Solv: benzene (71-43-2))

Boiling point:

469.0±45.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

17.25±0.40(Predicted)

color 

Pale Grey to Black

InChI

InChI=1/C17H18N2O2/c1-19-9-11(17(20)21-2)6-13-12-4-3-5-14-16(12)10(8-18-14)7-15(13)19/h3-6,8,11,15,18H,7,9H2,1-2H3/t11?,15-/s3

InChIKey

RNHDWLRHUJZABX-RXHCFGRJNA-N

SMILES

C12C3C=CC=C4NC=C(C[C@@]1([H])N(C)CC(C(OC)=O)C=2)C=34 |&1:10,r|

D-Lysergic Acid Methyl Ester Usage And Synthesis

Description

Lysergic acid methyl ester is an analogue of lysergic acid diethylamide (LSD). It is a member of the tryptamine family and is extremely uncommon. It acts on the 5-HT receptors in the brain, as do most tryptamines.

Uses

D-Lysergic Acid Methyl Ester is used in preparation of Serotonin agonists.It is an impurity of Lysergic Acid (L488000). Lysergic Acid and Iso-lysergic Acid are the main cleavage products formed on alkaline hydrolysis of the alkaloids which are characteristic of ergot. Potent hallucinogen; non-selective serotonin receptor agonist.

Preparation

synthesis of lysergic acid methyl ester: A suspension is prepared from 5.0 g of isolysergic acid amide in 80 ml of anhydrous methanol; the mixture is cooled to about -50°C and, under agitation, 40 ml of a 13N solution of hydrogen chloride in anhydrous methanol is added thereto. The clear solution is allowed to warm up to room temperature and further stirred overnight. The primary amount of the thus-formed ester hydrochloride is thus crystallized. By cooling in an ice bath and adding ethyl acetate, the crystallization is completed, and the precipitate is vacuum-filtered. Yield: 5.2 g (84% of theory) of lysergic acid methyl ester, hydrochloride.

D-Lysergic Acid Methyl Ester(4579-64-0)Related Product Information

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