L-DIHYDROOROTIC ACID Chemical Properties

Melting point:

254-255 °C (dec.)(lit.)

Boiling point:

283.16°C (rough estimate)

Density 

1.523

refractive index 

1.5090 (estimate)

storage temp. 

Sealed in dry,2-8°C

solubility 

DMSO (Slightly), Water (Slightly, Heated, Sonicated)

pka

2.82±0.20(Predicted)

form 

Powder

color 

White to off-white

Water Solubility 

Soluble in water (partly), and dimethyl formamide.

InChIKey

UFIVEPVSAGBUSI-REOHCLBHSA-N

CAS DataBase Reference

5988-19-2(CAS DataBase Reference)

NIST Chemistry Reference

Orotic acid, dihydro-, l-(5988-19-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

L-DIHYDROOROTIC ACID Usage And Synthesis

Chemical Properties

White to off-white crystalline powder

Uses

L-Dihydroorotic acid a metabolite.

Definition

ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.

Biochem/physiol Actions

L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.

L-DIHYDROOROTIC ACID(5988-19-2)Related Product Information

• Uridine-5'-diphosphate disodium salt
• Orotic acid
• Sodium phosphate tribasic dodecahydrate
• Trisodium phosphate
• Cytidine 5′-(tetrahydrogen triphosphate), xsodium salt, hydrate
• Sulbactum Sodium
• D-HYDROOROTIC ACID
• DL-Hydroorotic acid
• 1-METHYL-L-4,5-DIHYDROOROTIC ACID
• L-DIHYDROOROTIC ACID
• ATP disodium salt
• CTP xsodium
• Inosine
• Cytidine-5'-diphosphate disodium salt
• 2'-Deoxyuridine
• URIDINE 5'-DIPHOSPHORIC ACID SODIUM SALT
• UDP SODIUM SALT
• (S)-BENZYL 1-METHYL-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE