L-DIHYDROOROTIC ACID
L-DIHYDROOROTIC ACID Basic information
- Product Name:
- L-DIHYDROOROTIC ACID
- Synonyms:
-
- L-DIHYDROOROTIC ACID
- L-HYDROOROTIC ACID
- DIHYDRO-L-OROTIC ACID
- (S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
- 2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
- L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
- (S)-(+)-HYDROOROTIC ACID
- (4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid
- CAS:
- 5988-19-2
- MF:
- C5H6N2O4
- MW:
- 158.11
- EINECS:
- 624-952-7
- Product Categories:
-
- Heterocycles
- Miscellaneous Biochemicals
- Amino Acid Derivatives
- 5988-19-2
- Mol File:
- 5988-19-2.mol
L-DIHYDROOROTIC ACID Chemical Properties
- Melting point:
- 254-255 °C (dec.)(lit.)
- Boiling point:
- 283.16°C (rough estimate)
- Density
- 1.523
- refractive index
- 1.5090 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Water (Slightly, Heated, Sonicated)
- pka
- 2.82±0.20(Predicted)
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble in water (partly), and dimethyl formamide.
- InChI
- InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1
- InChIKey
- UFIVEPVSAGBUSI-REOHCLBHSA-N
- SMILES
- C1(=O)NC(=O)C[C@@H](C(O)=O)N1
- CAS DataBase Reference
- 5988-19-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Orotic acid, dihydro-, l-(5988-19-2)
MSDS
- Language:English Provider:SigmaAldrich
L-DIHYDROOROTIC ACID Usage And Synthesis
Chemical Properties
White to off-white crystalline powder
Uses
L-Dihydroorotic acid a metabolite.
Definition
ChEBI: (S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.
Biochem/physiol Actions
L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.
IC 50
Microbial Metabolite; Human Endogenous Metabolite
L-DIHYDROOROTIC ACID Preparation Products And Raw materials
Preparation Products
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L-DIHYDROOROTIC ACID(5988-19-2)Related Product Information
- Uridine-5'-diphosphate disodium salt
- Orotic acid
- Sodium phosphate tribasic dodecahydrate
- Trisodium phosphate
- Cytidine 5′-(tetrahydrogen triphosphate), xsodium salt, hydrate
- Sulbactum Sodium
- D-HYDROOROTIC ACID
- DL-Hydroorotic acid
- 1-METHYL-L-4,5-DIHYDROOROTIC ACID
- L-DIHYDROOROTIC ACID
- ATP disodium salt
- CTP xsodium
- Inosine
- Cytidine-5'-diphosphate disodium salt
- 2'-Deoxyuridine
- URIDINE 5'-DIPHOSPHORIC ACID SODIUM SALT
- UDP SODIUM SALT
- (S)-BENZYL 1-METHYL-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLATE