N-Octyl pyrrolidone Chemical Properties

Melting point:

−25 °C(lit.)

Boiling point:

170-172 °C15 mm Hg(lit.)

Density 

0.92 g/mL at 25 °C(lit.)

vapor pressure 

0.03-0.08Pa at 20℃

refractive index 

n20/D 1.465(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

pka

-0.42±0.20(Predicted)

color 

Colorless to Yellow

Specific Gravity

0.92

Water Solubility 

1.14-1.25g/L at 20℃

BRN 

1526318

InChIKey

WPPOGHDFAVQKLN-UHFFFAOYSA-N

LogP

4.15 at 20℃

CAS DataBase Reference

2687-94-7(CAS DataBase Reference)

EPA Substance Registry System

N-Octyl-2-pyrrolidone (2687-94-7)

Safety Information

Hazard Codes 

C,N

Risk Statements 

34-51/53

Safety Statements 

23-26-36/37/39-45-1/2

RIDADR 

UN 3267 8/PG 2

WGK Germany 

2

RTECS 

UY5896000

HazardClass 

8

PackingGroup 

III

HS Code 

29339900

Toxicity

LD50 orl-rat: 2050 mg/kg FCTOD7 26,475,88

MSDS

• Language:English Provider:SigmaAldrich

N-Octyl pyrrolidone Usage And Synthesis

Synthesis

N-Octyl pyrrolidone was synthesized by 2-pyrrolidone and tetrabutylammonium bromide stirred with adding n-octane chloride for 10 h at 90 °C.

Chemical Properties

Colorless or slightly yellow clear liquid

Uses

N-Octyl pyrrolidone(NOP) is a highly efficient and selective solvent, which can be used in the recovery of organic raw materials, the refining of lubricating oils, and the solvent for polymers and polymerization reactions; It is also widely used in chemical synthesis reactions.

Definition

ChEBI: N-Octyl-2-pyrrolidone is a N-alkylpyrrolidine.

Synthesis Reference(s)

The Journal of Organic Chemistry, 57, p. 3328, 1992 DOI: 10.1021/jo00038a019

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 6378, 1994 DOI: 10.1021/jo00100a046

General Description

1-Octyl-2-pyrrolidone is a permeation enhancer and its effect in transport of steroidal permeants across hairless mouse skin was investigated via a parallel pathway skin model.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by ingestion. Asevere skin and eye irritant. A corrosive. Combustibleliquid. When heated to decomposition it emits toxic fumesof NOx.

N-Octyl pyrrolidone (2687-94-7)Related Product Information

• Povidone iodine
• 2,5-Dimethylpyrrolidine
• N-Vinyl-2-pyrrolidone
• Polyvinylpyrrolidone
• 2-Pyrrolidinone
• N-Methyl-2-pyrrolidone
• METHYL-2-PYRROLIDONE
• Octyldodecyldimethylammonium chloride
• Poly(1-vinylpyrrolidone-co-vinyl acetate)
• Polyquaternium-11
• N-VINYLPYRROLIDONE/STYRENE COPOLYMER
• 1-Lauryl-2-pyrrolidone
• Sulfo-NHS-Biotin
• ALPHA-PYRIDOIN
• 1-(1-ADAMANTYLMETHYL)-2-PYRROLIDINONE
• CAPRYLYL PYRROLIDONE
• N-Octyl pyrrolidone
• 1-dodecanoyl-2-pyrrolidinone