Rilmenidine
Rilmenidine Basic information
- Product Name:
- Rilmenidine
- Synonyms:
-
- n-(dicyclopropylmethyl)-4,5-dihydro-2-oxazolamine
- oxaminozoline
- RILMENIDINE
- 1,1-dicyclopropyl-n-(2-oxazolinyl)-methylamin
- 2-((dicyclopropylmethyl)imino)-oxazolidin
- 2-((dicyclopropylmethyl)imino)oxazolidine
- 2-(dicyclopropylmethylamino)-2-oxazoline
- 4,5-dihydro-n-(dicyclopropylmethyl)-2-oxazolamin
- CAS:
- 54187-04-1
- MF:
- C10H16N2O
- MW:
- 180.25
- EINECS:
- 259-021-0
- Product Categories:
-
- Antihypertensive
- Imidazoline binding site
- Mol File:
- 54187-04-1.mol
Rilmenidine Chemical Properties
- Melting point:
- 106-107°
- Boiling point:
- 355.5±9.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- H2O: 7.3 mg/mL
- form
- solid
- pka
- 7.88±0.50(Predicted)
- color
- white
- CAS DataBase Reference
- 54187-04-1(CAS DataBase Reference)
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- RTECS
- RP7207400
MSDS
- Language:English Provider:Oxaminozoline
Rilmenidine Usage And Synthesis
Description
Rilmenidine is a new antihypertensive agent with a selective alphaz-agonist/antagonist profile, reportedly useful in the management of mild to moderate hypertension. Its fmt-line indication is possible because of the clear dissociation of its antihypertensive activity from other neurophannacological effects.
Chemical Properties
water soluble
Originator
Servier (France)
Uses
I1-imidazoline binding site ligand and a2-adrenoceptor agonist, exhibits higher I1 vs. a2 selectivity than clonidine
Definition
ChEBI: Rilmenidine is an isourea.
brand name
Hyperium
Biological Activity
I 1 -imidazoline binding site selective ligand and α 2 -adrenoceptor agonist. Possesses greater I 1 vs α 2 selectivity than the prototypical compound, clonidine.
Metabolic pathway
In short-term rat hepatocyte cultures, oxaminozoline is metabolized and its four metabolites resulting from oxidation or hydrolysis are identified, three of which are identical to those reported in vivo. The presence of an additional minor metabolite in culture may be due to the higher metabolic rate of oxaminozoline in this model system.
Rilmenidine Preparation Products And Raw materials
Raw materials
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Rilmenidine(54187-04-1)Related Product Information
- 3-Methyl-2-butanone
- Dihydromyrcenol
- N,N-Diisopropylethylamine
- Tolyltriazole
- 5-Methyl-1H-benzotriazole
- Chloromethyl isopropyl carbonate
- Cyclopropyl methyl ketone
- Allylamine
- Dicyclopropane methylamine
- (R)-1-(Cyclopropylethyl)amine
- (S)-1-CYCLOPROPYLETHYLAMINE
- RILMENIDINE DIHYDROGEN PHOSPHATE,rilmenidine phosphate
- O-METHYLISOUREA ACETATE
- RILMENIDINE FOR SYSTEM SUITABILITY
- Oxazoline
- RILMENIDINE DIHYDROGENOPHOSPHATE - REFERENCE SPECTRUM
- RILMENIDINE HEMIFUMARATE SALT
- CHEMBRDG-BB 4003538