N,N-Dimethylpiperidin-4-amine Chemical Properties

Boiling point:

187°C

Density 

1.09g/ml

Flash point:

187°C

refractive index 

1.4760

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

liquid

pka

10.10±0.10(Predicted)

color 

Clear, colourless

BRN 

1190

CAS DataBase Reference

50533-97-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

10-34-22

Safety Statements 

26-36/37/39-45

RIDADR 

2734

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

III

HS Code 

2933399990

N,N-Dimethylpiperidin-4-amine Usage And Synthesis

Uses

4-(Dimethylamino)piperidine is having molecular features associated with polyamine modulation of N-methyl-D-aspartate receptors. It is utilized as a mechanism for reducing the effects of alcohol dependence.

Synthesis

1-(tert-Butoxycarbonyl)-4-piperidone (998 mg, 4.75 mmol) in methanol (15 mL) was treated with dimethylamine hydrochloride (800 mg, 9.8 mmol) and sodium cyanoborohydride (270 mg, 4.3 mmol) at rt. After 4 days, concentrated HCl (10 mL) was added and the reaction was reduced in vacuo. The resulting residue was dissolved in H2O (30 mL) and treated with 2M NaOH solution to achieve a pH of 10. The aqueous solution was extracted with methylene chloride (3×20 mL) and the combined organics were dried over Na2SO4 and removed in vacuo. The resulting product is N,N-Dimethylpiperidin-4-amine (169 mg).

storage

Incompatible with air, water, oxidizing agents and heat.

N,N-Dimethylpiperidin-4-amine(50533-97-6)Related Product Information

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• 3-Dimethylaminopropylamine
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• Haloperidol
• Dibenzylamine
• 4-Dimethylaminobenzoic acid
• Triallylamine
• 4-Dimethylaminopyridine
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• 4-(2-KETO-1-BENZIMIDAZOLINYL)PIPERIDINE
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• 2-Dimethylaminoethanol
• FLUSPIRILENE