HOOCCH2CH2O-PEG10-CH2CH2COOH
HOOCCH2CH2O-PEG10-CH2CH2COOH Basic information
- Product Name:
- HOOCCH2CH2O-PEG10-CH2CH2COOH
- Synonyms:
-
- HOOCCH2CH2O-PEG10-CH2CH2COOH
- HOOCCH2CH2-PEG10-CH2CH2COOH
- 4,7,10,13,16,19,22,25,28,31,34-Undecaoxaheptatriacontanedioic acid
- Di-Acid-PEG11
- HOOCCH2CH2O-PEG10-CH2CH2COOH/4,7,10,13,16,19,22,25,28,31,34-undecaoxaheptatriacontane-1,37-dioic acid
- CAS:
- 2097010-30-3
- MF:
- C26H50O15
- MW:
- 602.67
- Product Categories:
-
- peg
- Mol File:
- 2097010-30-3.mol
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HOOCCH2CH2O-PEG10-CH2CH2COOH Chemical Properties
- Boiling point:
- 684.6±55.0 °C(Predicted)
- Density
- 1.165±0.06 g/cm3(Predicted)
- pka
- 3.97±0.10(Predicted)
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HOOCCH2CH2O-PEG10-CH2CH2COOH Usage And Synthesis
Biological Activity
Bis-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
HOOCCH2CH2O-PEG10-CH2CH2COOHSupplier
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