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HOOCCH2CH2O-PEG10-CH2CH2COOH

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HOOCCH2CH2O-PEG10-CH2CH2COOH Basic information

Product Name:
HOOCCH2CH2O-PEG10-CH2CH2COOH
Synonyms:
  • HOOCCH2CH2O-PEG10-CH2CH2COOH
  • HOOCCH2CH2-PEG10-CH2CH2COOH
  • 4,7,10,13,16,19,22,25,28,31,34-Undecaoxaheptatriacontanedioic acid
  • Di-Acid-PEG11
  • HOOCCH2CH2O-PEG10-CH2CH2COOH/4,7,10,13,16,19,22,25,28,31,34-undecaoxaheptatriacontane-1,37-dioic acid
CAS:
2097010-30-3
MF:
C26H50O15
MW:
602.67
Product Categories:
  • peg
Mol File:
2097010-30-3.mol
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HOOCCH2CH2O-PEG10-CH2CH2COOH Chemical Properties

Boiling point:
684.6±55.0 °C(Predicted)
Density 
1.165±0.06 g/cm3(Predicted)
pka
3.97±0.10(Predicted)
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HOOCCH2CH2O-PEG10-CH2CH2COOH Usage And Synthesis

Biological Activity

Bis-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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