ANTI-CD56 Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

mouse

Safety Information

Hazard Codes 

Xn

Risk Statements 

21/22-22

Safety Statements 

36/37

WGK Germany 

3

Storage Class

12 - Non Combustible Liquids

MSDS

• Language:English Provider:SigmaAldrich

ANTI-CD56 Usage And Synthesis

Uses

Monoclonal Anti-HNK-1/N-CAM (CD57) antibody produced in mouse has been used:

• as primary antibody for western blot analysis
• immunocytochemistry
• immunocytochemical
• immunohistological staining

General Description

Monoclonal Anti-HNK-1/N-CAM (CD57) (mouse IgM isotype) is derived from the VC1.1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Human natural killer cell -1 (HNK-1), also referred as B3GAT1, NK1, CD57, LEU7, NK-1, GLCATP and GLCUATP, is mapped to human chromosome 11q25. The encoded protein belongs to the glucuronyltransferase gene family. Neural cell-adhesion molecule (N-CAM) is expressed on all neuroepithelial cells from the time of neural induction in the early embryo. It is known that the sulfated carbohydrate HNK-1 epitope is carried by several surface molecules including a proportion of N-CAM isoforms.

Biochem/physiol Actions

HNK1 (human natural killer-1) is referred as B3GAT1, NK1, CD57, LEU7, NK-1, GLCATP and GLCUATP. It is a member of the glucuronyltransferase gene family. Human natural killer-1 (HNK1) carbohydrate epitope is expressed on various cell adhesion molecules in the nervous system and plays a role in cell-cell and cell-substrate interactions. HNK-1 epitope stabilizes GluR2 on neuronal surface membranes and regulates cell surface stability of GluR2 by modulating the interaction with N-cadherin. It is also plays a role in cell migration and synaptic plasticity. HNK-1 epitope has been associated with the risk of metastasis. It is observed to be highly expressed in melanoma cell lines.

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