Basic information Description Preparation Safety Supplier Related
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4-Pyridyl acetone

Basic information Description Preparation Safety Supplier Related

4-Pyridyl acetone Basic information

Product Name:
4-Pyridyl acetone
Synonyms:
  • 1-(4-Pyridyl)-2-propanone
  • 4-Pyridinolacetone
  • (4-Pyridyl)acetone,98%
  • 1-(4-Pyridinyl)-2-propanone CAS:
  • (4-PYRIDINEYL)-ACETONE
  • 1-(4-Pyridyl)-2-acetone
  • Einecs 228-605-7
  • 1-pyridin-4-ylacetone
CAS:
6304-16-1
MF:
C8H9NO
MW:
135.16
EINECS:
228-605-7
Product Categories:
  • Pyridines
Mol File:
6304-16-1.mol
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4-Pyridyl acetone Chemical Properties

Melting point:
13°C
Boiling point:
143°C 20mm
Density 
1.046±0.06 g/cm3(Predicted)
refractive index 
1.5225
Flash point:
143°C/20mm
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Oil
pka
4.90±0.10(Predicted)
color 
Light Brown to Brown
Water Solubility 
Slightly soluble in water.
BRN 
110960
InChIKey
ILRVKOYYFFNXDB-UHFFFAOYSA-N
CAS DataBase Reference
6304-16-1(CAS DataBase Reference)
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Safety Information

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-37
HS Code 
29337900

MSDS

  • Language:English Provider:ALFA
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4-Pyridyl acetone Usage And Synthesis

Description

1-(4-pyridyl)acetone is a yellow liquid, which is a key intermediate for synthesizing cardiac drug Milrinone.

Preparation

4-Pyridyl acetone can be prepared by reacting with 4-picoline and phenyllithium and ethyl acetate.

Physical properties

4-pyridyl acetone is a Light yellow to yellow liquid.

Uses

(4-Pyridyl)acetone is a reactant in the synthesis of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 3297, 1984 DOI: 10.1016/S0040-4039(01)81368-X

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