4-Pyridyl acetone Chemical Properties

Melting point:

13°C

Boiling point:

143°C 20mm

Density 

1.046±0.06 g/cm3(Predicted)

refractive index 

1.5225

Flash point:

143°C/20mm

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Oil

pka

4.90±0.10(Predicted)

color 

Light Brown to Brown

Water Solubility 

Slightly soluble in water.

BRN 

110960

InChI

InChI=1S/C8H9NO/c1-7(10)6-8-2-4-9-5-3-8/h2-5H,6H2,1H3

InChIKey

ILRVKOYYFFNXDB-UHFFFAOYSA-N

SMILES

C(C1C=CN=CC=1)C(=O)C

CAS DataBase Reference

6304-16-1(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-37

HS Code 

29337900

MSDS

• Language:English Provider:ALFA

4-Pyridyl acetone Usage And Synthesis

Description

1-(4-pyridyl)acetone is a yellow liquid, which is a key intermediate for synthesizing cardiac drug Milrinone.

Preparation

4-Pyridyl acetone can be prepared by reacting with 4-picoline and phenyllithium and ethyl acetate.

Physical properties

4-pyridyl acetone is a Light yellow to yellow liquid.

Uses

(4-Pyridyl)acetone is a reactant in the synthesis of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic.

Synthesis Reference(s)

Tetrahedron Letters, 25, p. 3297, 1984 DOI: 10.1016/S0040-4039(01)81368-X

4-Pyridyl acetone(6304-16-1)Related Product Information

• Benzenesulfonyl chloride
• Trifluoromethanesulfonic acid
• Pyrazine
• Acetone
• 4-Pyridyl acetone
• 3-HYDROXY-2-PYRIDIN-4-YL-INDEN-1-ONE
• 2-QUINOLIN-4-YL-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANONE
• 1-(4-METHOXY-PHENYL)-2-PYRIDIN-4-YL-ETHANONE
• 2-PYRIDIN-4-YL-1-P-TOLYL-ETHANONE
• 1-PHENYL-2-PYRIDIN-4-YL-ETHANONE
• 1-(4-CHLORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE
• 1-(4-FLUORO-PHENYL)-2-PYRIDIN-4-YL-ETHANONE
• 2-PYRIDIN-4-YL-1-(4-TRIFLUOROMETHYL-PHENYL)-ETHANONE
• RARECHEM AK HZ 0058
• 2-(4-PYRIDYL)INDANE-1,3-DIONE
• 2-(9-ACRIDINYL)-1-PHENYLETHANONE
• 4-Pyridinyl[3-(trifluoromethyl)phenyl]-ethanedione