Fluoroacetonitrile Chemical Properties

Melting point:

-13 °C

Boiling point:

79-80 °C (lit.)

Density 

1.061 g/mL at 25 °C (lit.)

refractive index 

1.333

Flash point:

7°F

Water Solubility 

Slightly soluble in water

form 

clear liquid

color 

Colorless to Almost colorless

CAS DataBase Reference

503-20-8(CAS DataBase Reference)

NIST Chemistry Reference

Fluoroacetonitrile(503-20-8)

Safety Information

Hazard Codes 

F;T,T,F

Risk Statements 

11-23/24/25-36/37/38

Safety Statements 

16-26-27-36/37/39-45

RIDADR 

UN 3273

WGK Germany 

3

RTECS 

AM0175000

HazardClass 

3.1

PackingGroup 

II

HS Code 

2926907090

Fluoroacetonitrile Usage And Synthesis

Uses

Fluoroacetonitrile is a water disinfectant byproduct that showed weak inhibition of rat hepatic glutathione S-transferases in vitro. Fluoroacetonitrile is also a reagent in the preparation of the PAD4 inhibitor F-Amidine.

Uses

Fluoroacetonitrile has been used in preparation of:

• 2-fluoromethyl-4,4,6-trimethyl-1,3-oxazine
• α-fluorinated acetophenone
• 2-amino-2-fluoromethyl-3-pentenenitrile, a key intermediate in the synthesis of 2,5-diamino-2-fluoromethyl-3(E)-pentenoic acid

Synthesis Reference(s)

Journal of Medicinal Chemistry, 26, p. 1551, 1983 DOI: 10.1021/jm00365a002

Fluoroacetonitrile(503-20-8)Related Product Information

• Iminodiacetonitrile
• Trifluoroacetonitrile
• Glycolonitrile
• Benzeneacetonitrile
• HEPTAFLUOROBUTYRONITRILE
• 4-Fluoroacetonitrile
• DIFLUOROACETONITRILE
• PERFLUORODECANONITRILE
• PERFLUOROHEPTANENITRILE
• PERFLUOROSEBACONITRILE
• PERFLUOROOCTANONITRILE
• perfluoroglutaronitrile
• 2,4-DIBROMO-5-CHLOROOCTAFLUOROPENTANONITRILE
• OCTAFLUOROADIPONITRILE
• 2,2,3,3-TETRAFLUOROSUCCINONITRILE
• BROMODIFLUOROACETONITRILE
• 2,2,3,3,4,4,5,5-OCTAFLUOROPENTANENITRILE
• PENTAFLUOROPROPIONITRILE