4-(Bromomethyl)tetrahydropyran Chemical Properties

Boiling point:

88 °C

Density 

1.359±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

form 

liquid

color 

Light beige/brown

InChI

InChI=1S/C6H11BrO/c7-5-6-1-3-8-4-2-6/h6H,1-5H2

InChIKey

LMOOYAKLEOGKJR-UHFFFAOYSA-N

SMILES

C1OCCC(CBr)C1

CAS DataBase Reference

125552-89-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

C,Xn

Risk Statements 

36/37/38-34-22

Safety Statements 

26-36/37/39-45-23

RIDADR 

3265

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

Ⅲ

HS Code 

29339900

4-(Bromomethyl)tetrahydropyran Usage And Synthesis

Chemical Properties

Viscous liquid

Uses

4-(Bromomethyl)tetrahydropyran is an important organic synthesis intermediate, widely used in the fields of medicine, pesticides and dyes. It can be used to synthesize a variety of biologically active compounds, such as antibacterial agents, anti-tumor drugs, nervous system drugs and fluorescent dyes. In addition, 4-(Bromomethyl)tetrahydropyran can also be used to synthesize organic pigments and functional materials.

Synthesis

To a solution of Tetrahydropyran-4-methanol and N-bromobutanimide (NBS) in DCM was added PPh3 at 0°C. The reaction mixture was stirred at room temperature for 1–2h. The resulting mixture was washed with water (20mL) and brine (3×20mL). The organic layer was concentrated and the residue was purified by silica gel flash chromatography (eluting with ethyl acetate in petroleum ether 2–5%) to give 4-(Bromomethyl)tetrahydropyran as a colorless oil.

4-(Bromomethyl)tetrahydropyran(125552-89-8)Related Product Information

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