4-Amino-2,5-dimethylphenol Chemical Properties

Melting point:

242-243 °C (lit.)

Boiling point:

288.4±28.0 °C(Predicted)

Density 

1.118±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

form 

Powder

pka

pK1: 5.28(+1);pK2: 10.40(0) (25°C)

color 

White to beige

Stability:

Stable. Incompatible with acids, chloroformates, acid anhydrides, acid chlorides, strong oxidizing agents.

CAS DataBase Reference

3096-71-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-37/39-24/25

WGK Germany 

3

HS Code 

29222990

MSDS

• Language:English Provider:SigmaAldrich

4-Amino-2,5-dimethylphenol Usage And Synthesis

Chemical Properties

solid

Uses

4-Amino-2,5-dimethylphenol may be used in chemical synthesis studies.

Synthesis

GENERAL METHOD: A mixture of p-benzoquinone monoxime (1.26 mmol), SnCl2 (0.72 g, 3.80 mmol), 20 mL of CH2Cl2, and 0.2 mL of concentrated HCl was heated and refluxed for 16 hours. After completion of the reaction, CH2Cl2 was removed by distillation under reduced pressure. the residue was dissolved in ethyl acetate and washed with saturated aqueous NaHCO3. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give 4-amino-2,5-dimethylphenol as a solid product.

References

[1] Tetrahedron, 2014, vol. 70, # 39, p. 6963 - 6973
[2] Chemische Berichte, 1885, vol. 18, p. 570
[3] Chemische Berichte, 1887, vol. 20, p. 979
[4] Journal of the American Chemical Society, 1917, vol. 39, p. 2190
[5] Journal of the American Chemical Society, 2016, vol. 138, # 16, p. 5202 - 5205

4-Amino-2,5-dimethylphenol(3096-71-7)Related Product Information

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