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Phosphomycin calcium salt

Basic information Safety Supplier Related

Phosphomycin calcium salt Basic information

Product Name:
Phosphomycin calcium salt
Synonyms:
  • (1,2-epoxypropyl)-,calciumsalt(1:1),(1r,2s)-(-)-phosphonicaci
  • (3-methyloxiranyl)-,calciumsalt(1:1),(2r-cis)-phosphonicaci
  • calciumfosfomycin
  • calciumphosphomycin
  • calciumphosphonomycin
  • fosmicin
  • PHOSPHOMYCIN
  • PHOSPHOMYCIN CALCIUM SALT MONOHYDRATE
CAS:
26016-98-8
MF:
C3H9CaO4P
MW:
180.15
EINECS:
247-408-7
Product Categories:
  • chiral
  • Drug bulk
  • API
Mol File:
26016-98-8.mol
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Phosphomycin calcium salt Chemical Properties

storage temp. 
Inert atmosphere,2-8°C
solubility 
1 M HCl: soluble50mg/mL
form 
Solid
color 
White to off-white
InChI
InChI=1/C3H7O4P.Ca.2H/c1-2-3(7-2)8(4,5)6;;;/h2-3H,1H3,(H2,4,5,6);;;/t2-,3+;;;/s3
InChIKey
YMZJBJPWTXJQMR-MUWMCQJSSA-L
SMILES
P([C@H]1O[C@H]1C)(O)(O)=O.[Ca] |&1:1,3,r|
CAS DataBase Reference
26016-98-8(CAS DataBase Reference)
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Safety Information

WGK Germany 
2
RTECS 
SZ7895000
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Phosphomycin calcium salt Usage And Synthesis

Uses

Fosfomycin Calcium is a bacterial wall synthesis inhibitor.

Definition

ChEBI: Fosfomycin calcium is an organic molecular entity.

in vivo

Fosfomycin calcium (80 mg/kg; i.v.-i.v. or i.v.-p.o.) displays the protective effect on the nephrotoxicity of double beckacin, and is not affected by different administration routes[3].
Pharmacokinetic of Fosfomycin calcium in Rats[4]

Dibekacin Dose (mg)Vdss (l/kg)β (min-1)T1/2 (min)Urinary recovery (%)
300.2610.024428.485
Animal Model:Fischer 344 rats[3]
Dosage:320 mg/kg
Administration:Intramuscular injection, 5 schedules: 1 h, 0.5 h earlier than dibekacin, concomitantly, 0.5 h later and 1 h later; 11 days
Result:Reduced polyuria, proteinuria, enzymes and cytosine caused by dibecacin (40 mg/kg), followed by the previous treatment.
Animal Model:Dehydrated Wistar rat with acute renal failure (8-week-old)[4]
Dosage:120 mg/kg
Administration:Intravenous injection; once
Result:Recovered the exclusion rate of rats basically to normal, and improved the nephrotoxicity parameters.
Protects proximal tubular lysosomes from aminoglycosides by inhibiting myeloid formation and protecting the integrity of lysosomal membrane of rats treated with double bekacin.

Phosphomycin calcium salt Preparation Products And Raw materials

Raw materials

Phosphomycin calcium saltSupplier

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