(4-Fluorophenyl)acetone Chemical Properties

Boiling point:

106-107 °C/18 mmHg (lit.)

Density 

1.139 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.496(lit.)

Flash point:

197 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Methyl Acetate: 50 mg/ml

form 

clear liquid

color 

Light yellow to Yellow to Orange

Specific Gravity

1.139

Water Solubility 

insoluble

BRN 

1936697

InChI

InChI=1S/C9H9FO/c1-7(11)6-8-2-4-9(10)5-3-8/h2-5H,6H2,1H3

InChIKey

ZUEKIIWSVFBTCM-UHFFFAOYSA-N

SMILES

C(C1=CC=C(F)C=C1)C(=O)C

CAS DataBase Reference

459-03-0(CAS DataBase Reference)

NIST Chemistry Reference

(4-Fluorophenyl)acetone(459-03-0)

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

36/37/38

Safety Statements 

24/25

WGK Germany 

3

Hazard Note 

Flammable

HazardClass 

IRRITANT, FLAMMABLE

HS Code 

29147090

MSDS

• Language:English Provider:4-Fluorophenylacetone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

(4-Fluorophenyl)acetone Usage And Synthesis

Description

This intermediate, also known as (4-Fluorophenyl)acetone, presents as a dark yellow liquid. It is known to be insoluble in water. For best results, store in a tightly closed container in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. 4-Fluorophenylacetone is incompatible with strong oxidizing agents. This chemical is a combustible liquid.

Chemical Properties

clear yellow liquid

Uses

4-Fluorophenylacetone is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields. It is a haloarylacetone derivative used in a study of reversed enantiopreference of an ω-transaminase by a single-point mutation.

Application

(4-Fluorophenyl)acetone is a phenylacetic acid derivative that inhibits the 5-HT2 receptors. It has been shown to have inhibitory activities against dopamine and serotonin by acting as an agonist at the receptor. (4-Fluorophenyl)acetone also binds to nucleophilic sites on proteins, which may lead to inhibition of protein synthesis. Brevibacterium sp. strain P7 was used as a model system and it has found that it inhibited the growth of this bacterium by binding to the enzyme RNA polymerase, preventing transcription and replication.

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