Tocopheryl acetate Chemical Properties

Melting point:

-28°C

Boiling point:

224 °C0.3 mm Hg(lit.)

Density 

0.96 g/mL at 20 °C (lit.)

vapor density 

16.3 (vs air)

refractive index 

n20/D 1.497

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Practically insoluble in water, freely soluble in acetone, in anhydrous ethanol and in fatty oils.

form 

Viscous Liquid

Specific Gravity

0.962 (20/4℃)

color 

Clear yellow viscous liquid

Odor

Odorless

Water Solubility 

Immiscible with water.

Sensitive 

Air & Light Sensitive

Merck 

14,9495

BRN 

97512

InChIKey

ZAKOWWREFLAJOT-CEFNRUSXSA-N

LogP

12.260 (est)

CAS DataBase Reference

7695-91-2(CAS DataBase Reference)

NIST Chemistry Reference

(+)-«ALPHA»-tocopherol acetate(7695-91-2)

EPA Substance Registry System

2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate (7695-91-2)

Safety Information

Safety Statements 

24/25

WGK Germany 

1

RTECS 

GA8747000

F 

8-10-23

TSCA 

Yes

HS Code 

29362800

MSDS

• Language:English Provider:3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-yl acetate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Tocopheryl acetate Usage And Synthesis

Chemical Properties

Light yellow to yellow clear liquid

Uses

vitamin E acetate (tocopherol acetate) is an anti-oxidant with skinmoisturizing activity. given its free-radical scavenging properties, it is useful in uV protective products. Vitamin e acetate is commonly used to replace vitamin e because it is more stable and is converted to vitamin e by the body.

Uses

Vitamin E (α-tocopherol) occurs naturally in most vegetable oils. The highest concentrations are found in com, soybean oils, sunflower seed, wheat germ, rapeseed, alfalfa, and lettuce. It is claimed to have age-retardant properties. May produce erythemamultiforme-like eruptions. It is used in a number of cosmetic products; creams are used for scars, striae, and bums; in pharmaeeutical ereams and deodorants; as an antioxidant in foods.

Uses

All-rac-alpha-tocopheryl acetate for peak identification may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

Uses

anti-Altzheimer therapeutic

Definition

ChEBI: DL-alpha-Tocopherol acetate is a tocol.

General Description

DL-α-Tocopherol acetate is a stable ester form of vitamin E, widely used in the formulation of cosmetics for the prevention or correction of skin damage.

Hazard

A reproductive hazard.

Flammability and Explosibility

Non flammable

Contact allergens

Tocopherol and tocopheryl acetate are used mainly as antioxidants. Tocopheryl acetate, an ester of tocopherol (vitamin E), can induce allergic contact dermatitis.

Biochem/physiol Actions

Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by Homosapiens. DL-α-Tocopherol acetate can inhibit oxidation of linoleate.

Purification Methods

It is a viscous liquid which is purified by distillation under high vacuum under N2 or Ar and stored in sealed ampoules in the dark. It is considerably more stable to light and air than the parent unacetylated vitamin. It is insoluble in H2O but freely soluble in organic solvents. All eight stereoisomers have been synthesised. The commercially pure d-tocopheryl acetate (2R,4'R,8'R) has b 180-200o/0.7mm and [] D 20 +3.9o (c 5, EtOH); see above. [Cohen et al. Helv Chim Acta 64 1158 1981, Beilstein 17/4 V 169.]

Tocopheryl acetate(7695-91-2)Related Product Information

• Cellulose acetate
• Vitamin A
• Tocopherol
• Retinyl acetate
• Menadione
• Trenbolone acetate
• 2-Butoxyethyl acetate
• Ascorbic Acid
• Dihydromyrcenol
• Vinyl acetate
• 1-Methoxy-2-propyl acetate
• Triacetin
• Magnesium acetate
• Butyl acetate
• Sodium acetate
• Goserelin acetate
• Isopropyl acetate
• Ethyl acetate