Ethanesulfonyl chloride Chemical Properties

Melting point:

-70°C

Boiling point:

177 °C (lit.)

Density 

1.357 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.452(lit.)

Flash point:

182 °F

storage temp. 

Inert atmosphere,2-8°C

solubility 

soluble in dichloromethane,Ether

form 

Liquid

color 

Clear colorless to light yellow or light brownish to pinkish-purple

Water Solubility 

DECOMPOSES

Sensitive 

Moisture Sensitive

BRN 

773865

InChIKey

FRYHCSODNHYDPU-UHFFFAOYSA-N

CAS DataBase Reference

594-44-5(CAS DataBase Reference)

NIST Chemistry Reference

Ethanesulfonyl chloride(594-44-5)

EPA Substance Registry System

Ethanesulfonyl chloride (594-44-5)

Safety Information

Hazard Codes 

T

Risk Statements 

21/22-23-34-22

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2927 6.1/PG 2

WGK Germany 

3

RTECS 

KI8050000

F 

19-21

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29049090

Hazardous Substances Data

594-44-5(Hazardous Substances Data)

MSDS

• Language:English Provider:Ethanesulfonyl chloride
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Ethanesulfonyl chloride Usage And Synthesis

Chemical Properties

clear light brownish to pinkish-purple liquid

Uses

Chloroethylsulfone was used in discovery of a selective inhibitor of oncogenic B-raf kinase with potent antimelanoma activity.

Application

Ethanesulfonyl chloride can make sulfonyl-substituted imides, methide lithium salts, and pentafluoroethanesulfonyl fluoride, a fluorinated surfactant. It is an intermediate in synthesizing new, low-cost, non-fluorinated, sulfonyl-substituted imide and methide lithium salts and an intermediate in preparing the fluorinated surfactant pentafluoroethanesulfonyl fluoride.

Synthesis Reference(s)

Journal of the American Chemical Society, 61, p. 2548, 1939 DOI: 10.1021/ja01878a085

Ethanesulfonyl chloride(594-44-5)Related Product Information

• Ferric chloride
• Dansyl chloride
• Sulfuryl chloride
• Cyclopropanesulfonyl chloride
• Tosyl chloride
• Chloromethanesulfonyl chloride
• Sodium chloride
• Polyvinyl chloride
• Potassium chloride
• Benzenesulfonyl chloride
• 4-Nitrobenzenesulfonyl chloride
• alpha-Toluenesulfonyl chloride
• Methanesulfonyl chloride
• Choline chloride
• Calcium chloride
• Ammonium chloride
• Ethanesulfonamide
• Ethyl glycolate