Baloxavir Chemical Properties

Boiling point:

644.7±65.0 °C(Predicted)

Density 

1.63±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:41.67(Max Conc. mg/mL);86.19(Max Conc. mM)

form 

A solid

pka

4.50±1.00(Predicted)

color 

White to yellow

CAS DataBase Reference

1985605-59-1

Baloxavir Usage And Synthesis

Uses

Baloxavir is a drug employed in the treatment of influenza virus infection.
Baloxavir marboxil is a selective inhibitor of influenza cap-dependent endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B virus infections, including strains resistant to current antiviral agents.

Uses

Baloxavir is a drug employed in the treatment of influenza virus infection.

Mechanism of action

Baloxavir marboxil is an influenza therapeutic agent, specifically, an enzyme inhibitor targeting the influenza virus' cap-dependent endonuclease activity, one of the activities of the virus polymerase complex. In particular, it inhibits a process known as cap snatching, by which the virus derives short, capped primers from host cell RNA transcripts, which it then uses for polymerase-catalyzed synthesis of its needed viral mRNAs. A polymerase subunit binds to the host pre-mRNAs at their 5' caps, then the polymerase's endonuclease activity catalyzes its cleavage "after 10–13 nucleotides". As such, its mechanism is distinct from neuraminidase inhibitors such as oseltamivir and zanamivir.

Side effects

Common side effects following the single dose administration of baloxavir marboxil include diarrhea, bronchitis, common cold, headache, and nausea. Adverse events were reported in 21% of people who received baloxavir, 25% of those receiving placebo, and 25% of oseltamivir.

Baloxavir(1985605-59-1)Related Product Information

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