3-(4-Methoxyphenyl)propionic acid Chemical Properties

Melting point:

98-100 °C (lit.)

Boiling point:

194 °C / 15mmHg

Density 

1.144±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

pka

4.71±0.10(Predicted)

color 

White to Light yellow to Light orange

BRN 

1953326

InChI

InChI=1S/C10H12O3/c1-13-9-5-2-8(3-6-9)4-7-10(11)12/h2-3,5-6H,4,7H2,1H3,(H,11,12)

InChIKey

FIUFLISGGHNPSM-UHFFFAOYSA-N

SMILES

C1(CCC(O)=O)=CC=C(OC)C=C1

CAS DataBase Reference

1929-29-9(CAS DataBase Reference)

NIST Chemistry Reference

3-(4-Methoxyphenyl)propionic acid(1929-29-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-36-26

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29189900

MSDS

• Language:English Provider:3-(4-Methoxyphenyl)propionic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-(4-Methoxyphenyl)propionic acid Usage And Synthesis

Chemical Properties

White tolight beige crystalline powder

Uses

3-(4-Methoxyphenyl)propionic acid is a nutrient solution that can be used to inhibit microbial growth by binding to the active site of enzymes such as carbonyl group, formation rate, acidic ph, chlorogenic acids, cinnamic acid derivatives. 

Reactions

3-(4-Methoxyphenyl)propionic acid has been shown to react with hydrogen bond and diltiazem hydrochloride in surface methodology experiments.

Synthesis

A catalytic amount of 10% palladium/activated carbon was added to a solution of 3-(4-methoxyphenyl)acrylic acid (15 g, 14.7 mmol) in tetrahydrofuran (50 mL). The hydrogenation reaction was carried out at room temperature with continuous stirring for 5 hours. Upon completion of the reaction, the mixture was filtered to remove the catalyst and the filtrate was concentrated in vacuum to give the white solid product 3-(4-methoxyphenyl)propionic acid in 95.2% yield with a melting point of 102-103 °C.

References

[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 10, p. 3192 - 3203
[2] Pharmazie, 2010, vol. 65, # 12, p. 913 - 918
[3] Patent: CN106146450, 2016, A. Location in patent: Paragraph 0162; 0163; 0164
[4] Canadian Journal of Chemistry, 2012, vol. 90, # 9, p. 758 - 761
[5] Synthetic Communications, 2012, vol. 42, # 6, p. 893 - 904

3-(4-Methoxyphenyl)propionic acid(1929-29-9)Related Product Information

• Propionic anhydride
• 4-Methoxybenzyl alcohol
• Propionic acid
• o-Anisaldehyde
• 4-Methoxyphenylacetone
• 4-Methoxybenzyl cyanide
• 4-Methoxyphenylacetic acid
• m-Anisyl alcohol
• (Trifluoromethoxy)benzene
• Anisole
• p-Anisidine
• 4-Methoxybenzoic acid
• Methoxyacetic acid
• p-Anisaldehyde
• Liothyronine sodium
• 3-(4-ETHOXYPHENYL)PROPIONIC ACID
• Methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate
• 3-(3,4-METHYLENEDIOXYPHENYL)PROPIONIC ACID