Clopamide Chemical Properties

Melting point:

248-249℃

Density 

1.39±0.1 g/cm3(Predicted)

RTECS 

CV2338875

storage temp. 

2-8°C

solubility 

Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly)

pka

9.41±0.60(Predicted)

color 

Pale Yellow to Light Yellow

CAS DataBase Reference

636-54-4(CAS DataBase Reference)

EPA Substance Registry System

Benzamide, 3-(aminosulfonyl)-4-chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-, rel- (636-54-4)

Safety Information

Hazard Codes 

Xn

Risk Statements 

42/43

Safety Statements 

36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

Clopamide Usage And Synthesis

Chemical Properties

White or almost white, hygroscopic, crystalline powder

Originator

Brinaldix,Novartis

Uses

Antihypertensive; diuretic.

Uses

Antihypertensor;Gonad stimuling agent

Uses

Clopamide is a thiazide-like diuretic that inhibits sodium/chloride cotransporters in the proximal convoluted tubule of the kidney, which prevents the reabsorption of sodium and chloride. This compound is intended for research purposes only.

Definition

ChEBI: 4-chloro-N-[(2S,6R)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide is a sulfonamide.

Manufacturing Process

To a solution of 5.5 g of 3-chlorsulfonyl-4-chlorobenzoylchloride in 20 ml chlorobenzole 3.3 g of 1-amino-cis-2,6-dimethylpiperidin-hydrochloride slowly was added at room temperature. Reaction mixture was heated to 100°-105°C during 8 h, then it was cooled to room temperature. The precipitated crystals of N-[cis-2,6-dimethyl-piperidyl-(1)]-3-chlorsulfonyl-4-chlorobenzoylamide were filtered and dried at 100°C under vacuo, then was treated by ammonium at room temperature. The obtained product was chromatographed (aluminum oxide; eluent: chloroform-methanol 9:1 and methanol-ether) to give N-[cis- 2,6-dimethylpiperidyl-(1)]-3-sulfamyl-4-chlorbenzoylamide, melting point 235°-237°C.

brand name

Aquex (Novartis).

Therapeutic Function

Diuretic, Antihypertensive

Clopamide(636-54-4)Related Product Information

• N,N-Dimethyl-1,4-phenylenediamine
• Pamidronate disodium salt
• p-Aminobenzamide
• Chlorantraniliprole
• Chloroacetamide
• Cloperastine hydrochloride
• Loperamide hydrochloride
• Polyacrylamide
• Disodium pamidronate
• Trazodone
• Benzamide
• Difluorochloromethane
• PamidronicAcid
• cis-2,6-Dimethylpiperidine
• 2,6-Dimethylpiperidine
• Clopamide for system suitability
• Clopamide
• 4-t-Butylbenzamide