2-Hydroxycaprylic acid Chemical Properties

Melting point:

66-68 °C

Boiling point:

226.12°C (rough estimate)

Density 

1.0227 (rough estimate)

refractive index 

1.4310 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Solid

pka

3.86±0.21(Predicted)

color 

White to Off-White

BRN 

1760638

LogP

1.960 (est)

CAS DataBase Reference

617-73-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2918.19.9000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Hydroxycaprylic acid Usage And Synthesis

Uses

2-Hydroxyoctanoic acid is a medium chain acyl-CoA synthetase inhibitor with a Ki of 500 μM[1].

Definition

ChEBI: A hydroxy fatty acid that is caprylic (octanoic) acid substituted by a hydroxy group at position 2.

Biological Activity

(±)-2-Hydroxyoctanoic acid inhibits purified medium-chain acyl-CoA synthetase from bovine liver mitochondria (Ki, 500 uM) with hexanoic acid as a substrate .', '(±)-2-Hydroxyoctanoic acid is a mixture of the D and L-2-hydroxyoctanoic acid enantiomers. (±)-2-Hydroxyoctanoic acid may be used in the development of medium-chain hydroxy-fatty acid enantiomer separation and detection systems. 2-Hydroxyoctanoic acid may be used as an inhibitor to study the kinteics of medium chain acyl-CoA synthetase(s).

Purification Methods

Crystallise the acid from EtOH/pet ether or ether/ligroin. [Beilstein 3 IV 873.]

References

[1] F Kasuya, et al. Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids. Biochem Pharmacol. 1996 Nov 22;52(10):1643-6. DOI:10.1016/s0006-2952(96)00563-1

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