FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID Chemical Properties

Boiling point:

711.4±60.0 °C(Predicted)

Density 

1.210±0.06 g/cm3 (20 ºC 760 Torr)

storage temp. 

2-8°C

pka

4.28±0.10(Predicted)

form 

Liquid

color 

Colorless to light yellow

Safety Information

HS Code 

29225090

FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID Usage And Synthesis

Description

Fmoc-N-amido-PEG5-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Chemical Properties

Yellow oil

Uses

Fmoc-amino-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

reaction suitability

reaction type: Pegylations

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID(882847-32-7)Related Product Information

• FMOC-15-AMINO-4,7,10,13-TETRAOXAPENTADECANOIC ACID
• HO-PEG12-tBu
• FMOC-12-AMINO-4,7,10-TRIOXADODECANOIC ACID
• 2-[2-(2-Azidoethoxy)ethoxy]ethanamine
• MPEG4-CH2CH2COOH
• 2-[2-[2-[2-[2-(BENZYLOXY)ETHOXY]ETHOXY]ETHOXY]ETHOXY]ETHANOL
• FMOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID
• Fmoc-N-amido-PEG11-acid
• FMoc-NH-8(ethylene glycol)-acetic acid
• Fmoc-N-amido-PEG17-acid
• Fmoc-NH-PEG2-CH2CO2H
• FMoc-NH-5(ethylene glycol)-acetic acid
• Fmoc-NH-PEG3-CH2COOH
• Fmoc-N-amido-PEG15-acid
• 5,8,11,14,17,20,23,26-Octaoxa-2-azanonacosanedioic acid,1-(9-fluren-9-ylmethyl)ester
• Fmoc-N-amido-PEG14-acid
• FMoc-NH-PEG9-CH2CH2COOH
• FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID