(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE Chemical Properties

storage temp. 

Desiccate at +4°C

solubility 

H₂O: 1.7 mg/mL

form 

solid

color 

gray

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE Usage And Synthesis

Uses

(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal?regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.

Definition

ChEBI: 9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol is a benzazepine.

Biological Activity

Dopamine D 1 -like receptor agonist. Centrally active following systemic administration in vivo .

Biochem/physiol Actions

(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.

(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE(71636-61-8)Related Product Information

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