(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE Basic information
- Product Name:
- (+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
- Synonyms:
-
- (+/-)-SKF-81297 HYDROBROMIDE
- (+/-)-6-CHLORO-PB HYDROBROMIDE
- (+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
- 6-CHLORO-2,3,4,5-TETRAHYDRO-1-PHENYL-1H-3-BENZAZEPINE-7,8-DIOL HYDROBROMIDE
- SKF 81297 HYDROBROMIDE
- sk&f81297
- (+-)-6-CHLORO-PB HYDROBROMIDE (+-)-SKF-8 1297, HCL
- 6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepinehydrobromide
- CAS:
- 71636-61-8
- MF:
- C16H17BrClNO2
- MW:
- 370.67
- Product Categories:
-
- Dopamine receptor
- Mol File:
- 71636-61-8.mol
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE Chemical Properties
- storage temp.
- Desiccate at +4°C
- solubility
- H2O: 1.7 mg/mL
- form
- solid
- color
- gray
- Water Solubility
- H2O: 1.7mg/mL
DMSO: >10mg/mL
ethanol: 6.3mg/mL
MSDS
- Language:English Provider:SigmaAldrich
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE Usage And Synthesis
Uses
(±)-6-Chloro-PB hydrobromide has been used as a dopamine D1 receptor (Drd1a) agonist to study the role of the drd1a-dopamine receptor inactivation of extracellular signal?regulated protein kinase 1/2 (ERK1/2) in the wild-type and striatum of dopamine-depleted mice. It has also been used as a Drd1a agonist to identify the contribution of D1 (D1R)-like dopamine receptor signaling on learning and memory in Barnes maze in rats.
Definition
ChEBI: 9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol is a benzazepine.
Biological Activity
Dopamine D 1 -like receptor agonist. Centrally active following systemic administration in vivo .
Biochem/physiol Actions
(+/-)-6-Chloro-PB HBr is a full D1 dopamine receptor agonist.
in vivo
SKF 81297 (0.05-0.3 mg/kg, i.m., once) stimulates motor behaviour of MPTP-lesioned monkeys[1].
| Animal Model: | Four male rhesus monkeys (Macaca mulatta, 7.0-11.3 kg)[1] |
| Dosage: | 0.05-0.3 mg/kg |
| Administration: | Injected intramuscularly (i.m.), once |
| Result: | Significantly increased rotational behaviour and right-sided hand use in unilateral MPTP-lesioned rhesus monkeys. |
IC 50
D1 Receptor
(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDESupplier
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(+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE(71636-61-8)Related Product Information
- R(+)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
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- (+/-)-6-CHLORO-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
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- (+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE