K-11777
K-11777 Basic information
- Product Name:
- K-11777
- Synonyms:
-
- K-11777
- 4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide
- 1-Piperazinecarboxamide, 4-methyl-N-[(1S)-2-oxo-2-[[(1S)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propen-1-yl]amino]-1-(phenylmethyl)ethyl]-
- 4-Methyl-N-((S)-1-oxo-3-phenyl-1-(((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide
- K777, 10 mM in DMSO
- 4-Methyl-N-((S)-1-oxo-3-phenyl-1-(((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide , K777
- K-177
- CAS:
- 233277-99-1
- MF:
- C32H38N4O4S
- MW:
- 574.73
- Mol File:
- 233277-99-1.mol
More
Less
K-11777 Chemical Properties
- Boiling point:
- 861.0±65.0 °C(Predicted)
- Density
- 1.217±0.06 g/cm3(Predicted)
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 12.48±0.20(Predicted)
- color
- White to off-white
- SMILES
- CN1CCN(C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCC3=CC=CC=C3)/C=C/S(C4=CC=CC=C4)(=O)=O)=O)=O)CC1
More
Less
K-11777 Usage And Synthesis
Uses
K777 Hydrochloride-d8 is the labelled analogue of K777 Hydrochloride (K165805). It acts as a cathespin B inhibitor which may be useful in the therapeutic treatment of Chagas’ disease.
in vivo
K777 (K11777; 35-105 mg/kg; oral administration; twice a day; for 10 days; C57BL/6 IFN-γR-KO mice) treatment rescues mice from otherwise lethal infections[4] .
| Animal Model: | C57BL/6 IFN-γR-KO mice (6-8 weeks of age) injected with Cryptosporidium parvum[4] |
| Dosage: | 35 mg/kg, 70 mg/kg, and 105 mg/kg |
| Administration: | Oral administration; twice a day; for 10 days |
| Result: | Rescued mice from otherwise lethal infections. |
IC 50
CYP3; EBOV; MARV; CCR4; Trypanosoma
K-11777Supplier
Sichuan Wei Keqi Biological Technology Co., Ltd.
- Tel
- 028-81700200 18116577057
- 3003855609@qq.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai Hongye Biotechnology Co. Ltd
- Tel
- 400-9205774
- sales@glpbio.cn
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Guangzhou Younan Technology Co., Ltd
- Tel
- 020-82000279 18988941452
- YN_research@163.com