Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Pharmaceutical intermediates >  Heterocyclic compound >  K-11777

K-11777

Basic information Safety Supplier Related

K-11777 Basic information

Product Name:
K-11777
Synonyms:
  • K-11777
  • 4-methyl-N-((S)-1-oxo-3-phenyl-1-(((S,E)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide
  • 1-Piperazinecarboxamide, 4-methyl-N-[(1S)-2-oxo-2-[[(1S)-1-(2-phenylethyl)-3-(phenylsulfonyl)-2-propen-1-yl]amino]-1-(phenylmethyl)ethyl]-
  • 4-Methyl-N-((S)-1-oxo-3-phenyl-1-(((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide
  • K777, 10 mM in DMSO
  • 4-Methyl-N-((S)-1-oxo-3-phenyl-1-(((S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl)amino)propan-2-yl)piperazine-1-carboxamide , K777
  • K-177
CAS:
233277-99-1
MF:
C32H38N4O4S
MW:
574.73
Mol File:
233277-99-1.mol
More
Less

K-11777 Chemical Properties

Boiling point:
861.0±65.0 °C(Predicted)
Density 
1.217±0.06 g/cm3(Predicted)
solubility 
DMSO: soluble
form 
A solid
pka
12.48±0.20(Predicted)
color 
White to off-white
SMILES
CN1CCN(C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCC3=CC=CC=C3)/C=C/S(C4=CC=CC=C4)(=O)=O)=O)=O)CC1
More
Less

K-11777 Usage And Synthesis

Uses

K777 Hydrochloride-d8 is the labelled analogue of K777 Hydrochloride (K165805). It acts as a cathespin B inhibitor which may be useful in the therapeutic treatment of Chagas’ disease.

in vivo

K777 (K11777; 35-105 mg/kg; oral administration; twice a day; for 10 days; C57BL/6 IFN-γR-KO mice) treatment rescues mice from otherwise lethal infections[4] .

Animal Model:C57BL/6 IFN-γR-KO mice (6-8 weeks of age) injected with Cryptosporidium parvum[4]
Dosage:35 mg/kg, 70 mg/kg, and 105 mg/kg
Administration:Oral administration; twice a day; for 10 days
Result:Rescued mice from otherwise lethal infections.

IC 50

CYP3; EBOV; MARV; CCR4; Trypanosoma

K-11777Supplier

Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Email
3003855609@qq.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988941452
Email
YN_research@163.com