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CORTEXOLONE

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CORTEXOLONE Basic information

Product Name:
CORTEXOLONE
Synonyms:
  • (8R,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Hydrocortisone Impurity 6（Hydrocortisone EP Impurity F）
  • 11-DEOXYCORTISOL; CORTEXOLONE; REICHSTEIN'S SUBSTANCE S
  • 11-dioxy-cortiso
  • 11-dioxycortisol
  • 17,21-dihydroxy-pregn-4-ene-20-dione
  • 17-hydroxy-11-deoxycorticosterone
  • nsc-18317
CAS:
152-58-9
MF:
C21H30O4
MW:
346.46
EINECS:
205-805-2
Product Categories:
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Steroids
  • Biochemistry
  • Hydroxyketosteroids
  • Pharmaceuticals
  • Pharmaceutical Raw Materials
  • 152-58-9
  • 1
Mol File:
152-58-9.mol
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CORTEXOLONE Chemical Properties

Melting point:
205-208 °C
Boiling point:
401.19°C (rough estimate)
Density 
1.22±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
120 ° (C=1, Dioxane)
Flash point:
9℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
Dioxane (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
12?+-.0.60(Predicted)
color 
White to Off-White
Water Solubility 
44.08mg/L(37 ºC)
Merck 
14,2932
InChIKey
WHBHBVVOGNECLV-OBQKJFGGSA-N
CAS DataBase Reference
152-58-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
24/25-22-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
TU5011500
HS Code 
2937.23.5050
Toxicity
mouse,LD50,intravenous,100mg/kg (100mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04684,

MSDS

  • Language:English Provider:ACROS
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CORTEXOLONE Usage And Synthesis

Chemical Properties

Crystalline Solid

Uses

11-Deoxy Cortisol (Hydrocortisone EP Impurity F) is a glucocorticoid receptor binding.

Definition

ChEBI: 11-deoxycortisol is a deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen. It has a role as a mouse metabolite and a human metabolite. It is a glucocorticoid, a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone and a deoxycortisol.

CORTEXOLONESupplier

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