2-Fluorophenol Chemical Properties

Melting point:

16.1 °C (lit.)

Boiling point:

171-172 °C/741 mmHg (lit.)

Density 

1.256 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.511(lit.)

Flash point:

116 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

37.7g/l

form 

Liquid

pka

8.73(at 25℃)

Specific Gravity

1.256

color 

Clear colorless to light yellow-brownish

Water Solubility 

80.72g/L(25 ºC)

BRN 

1905112

Stability:

Stable. Flammable. Incompatible with strong oxidizing agents.

InChIKey

HFHFGHLXUCOHLN-UHFFFAOYSA-N

CAS DataBase Reference

367-12-4(CAS DataBase Reference)

NIST Chemistry Reference

Phenol, 2-fluoro-(367-12-4)

EPA Substance Registry System

o-Fluorophenol (367-12-4)

Safety Information

Hazard Codes 

Xn,F,C,Xi,T

Risk Statements 

20/21/22-36/37/38-10-63-43-23/24/25-45-40

Safety Statements 

28-36/37-36/37/39-26-16-24/25-23-53-36

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

RTECS 

SL4530000

Hazard Note 

Flammable/Corrosive

TSCA 

T

HazardClass 

3

PackingGroup 

III

HS Code 

29081000

MSDS

• Language:English Provider:2-Fluorophenol
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
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2-Fluorophenol Usage And Synthesis

Chemical Properties

Clear colourless to yellow liquid

Uses

2-Fluorophenol is a competitive inhibitor in the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA), a catecholamine precursor that is used as a therapeutic agent for patients with ParkinsonтАЩs disease. 2-Fluorophenol is also used as a sole carbon energy source for bacteria.

Synthesis Reference(s)

Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
Journal of the American Chemical Society, 103, p. 1964, 1981 DOI: 10.1021/ja00398a015

General Description

Liquid or crystalline solid melting at 14-16°C. Corrosive. Density 1.246 g / cm3.

Air & Water Reactions

Highly flammable.

Reactivity Profile

2-Fluorophenol reacts as a weak organic acid. May be incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction with bases. Such heating may initiate polymerization of the organic compound. Sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Nitrated very rapidly, even by dilute nitric acid.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic and irritant.

Purification Methods

Pass o-fluorophenol at least twice through a gas chromatographic column for small quantities; otherwise fractionally distil it under reduced pressure. [Beilstein 6 I 97, 6 IV 770.]

2-Fluorophenol(367-12-4)Related Product Information

• 2-Phenylphenol
• 2-Aminophenol
• 4-Aminophenol
• 2-tert-Butylphenol
• 2,6-Dimethylphenol
• 2,6-Difluorophenol
• SODIUM PHENOLATE TRIHYDRATE
• o-Cresol
• 2-Ethoxyphenol
• Guaiacol
• 2-Fluorobenzyl cyanide
• 2-Bromophenol
• 2-Brome-5-Fluorophenol,2-Bromo-5-fluorophenol 98%
• 2,6-DINITROPHENOL
• 3,4-Difluorophenol
• p-Fluorophenol,99%,4-Fluorophenol,99%
• 3,4,5-Trifluorophenol
• 2-Nitrophenol