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2-Fluorophenol

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2-Fluorophenol Basic information

Product Name:
2-Fluorophenol
Synonyms:
  • 2-Florophenol
  • 2-FLUOROHYDROXYBENZENE
  • 2-FLUOROPHENOL
  • 1-Fluoro-2-hydroxybenzene
  • 2-fluoro-pheno
  • 2-Hydroxyfluorobenzene
  • 2-Fluorophenol, 97+%
  • Adjacent fluorine phenol
CAS:
367-12-4
MF:
C6H5FO
MW:
112.1
EINECS:
206-681-2
Product Categories:
  • alcohol| alkyl Fluorine
  • Organic Fluorinated Building Blocks
  • Aryl Fluorinated Building Blocks
  • Building Blocks
  • Other Fluorinated Organic Building Blocks
  • Oxygen Compounds
  • 600 Series Wastewater Methods
  • Chemical Class
  • FluoroEPA
  • C6
  • C6 to C8
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Organic Building Blocks
  • Fluoro-Aromatics
  • Aromatic Phenols
  • Fluorobenzene
  • Phenol&Thiophenol&Mercaptan
  • Fluorine Compounds
  • Phenols
  • Organic Building Blocks
  • Oxygen Compounds
  • Alpha Sort
  • E-LAlphabetic
  • F
  • FA - FLChemical Class
  • Fluoro
  • Halogenated
  • Method 625
  • organofluorine compounds
  • Volatiles/ Semivolatiles
Mol File:
367-12-4.mol
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2-Fluorophenol Chemical Properties

Melting point:
16.1 °C (lit.)
Boiling point:
171-172 °C/741 mmHg (lit.)
Density 
1.256 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.511(lit.)
Flash point:
116 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
37.7g/l
form 
Liquid
pka
8.73(at 25℃)
Specific Gravity
1.256
color 
Clear colorless to light yellow-brownish
Water Solubility 
80.72g/L(25 ºC)
BRN 
1905112
Stability:
Stable. Flammable. Incompatible with strong oxidizing agents.
InChIKey
HFHFGHLXUCOHLN-UHFFFAOYSA-N
CAS DataBase Reference
367-12-4(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 2-fluoro-(367-12-4)
EPA Substance Registry System
o-Fluorophenol (367-12-4)
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Safety Information

Hazard Codes 
Xn,F,C,Xi,T
Risk Statements 
20/21/22-36/37/38-10-63-43-23/24/25-45-40
Safety Statements 
28-36/37-36/37/39-26-16-24/25-23-53-36
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
RTECS 
SL4530000
Hazard Note 
Flammable/Corrosive
TSCA 
T
HazardClass 
3
PackingGroup 
III
HS Code 
29081000

MSDS

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2-Fluorophenol Usage And Synthesis

Chemical Properties

Clear colourless to yellow liquid

Uses

2-Fluorophenol is a competitive inhibitor in the oxidation of 3,4-dihydroxyphenylalanine (L-DOPA), a catecholamine precursor that is used as a therapeutic agent for patients with ParkinsonтАЩs disease. 2-Fluorophenol is also used as a sole carbon energy source for bacteria.

Synthesis Reference(s)

Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
Journal of the American Chemical Society, 103, p. 1964, 1981 DOI: 10.1021/ja00398a015

General Description

Liquid or crystalline solid melting at 14-16°C. Corrosive. Density 1.246 g / cm3.

Air & Water Reactions

Highly flammable.

Reactivity Profile

2-Fluorophenol reacts as a weak organic acid. May be incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction with bases. Such heating may initiate polymerization of the organic compound. Sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Nitrated very rapidly, even by dilute nitric acid.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic and irritant.

Purification Methods

Pass o-fluorophenol at least twice through a gas chromatographic column for small quantities; otherwise fractionally distil it under reduced pressure. [Beilstein 6 I 97, 6 IV 770.]

2-Fluorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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