BENFLUOREX HYDROCHLORIDE
BENFLUOREX HYDROCHLORIDE Basic information
- Product Name:
- BENFLUOREX HYDROCHLORIDE
- Synonyms:
-
- benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester
- Ethanol, 2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]-, benzoate
- jp992
- Minolip
- n-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethyl-phenethylaminbenzoate
- N-(2-Hydroxyethyl)-alpha-methyl-m-trifluoromethylphenethylamine benzoate
- n-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethylphenethylaminebenzoate
- Phenethylamine, N-(2-hydroxyethyl)-alpha-methyl-m-trifluoromethyl-, benzoate
- CAS:
- 23602-78-0
- MF:
- C19H20F3NO2
- MW:
- 351.36
- EINECS:
- 245-777-9
- Product Categories:
-
- MINOLIP
- Mol File:
- 23602-78-0.mol
BENFLUOREX HYDROCHLORIDE Chemical Properties
- Boiling point:
- 420.5±45.0 °C(Predicted)
- Density
- 1.183±0.06 g/cm3(Predicted)
- pka
- 8.23±0.10(Predicted)
BENFLUOREX HYDROCHLORIDE Usage And Synthesis
Originator
Mediator,Servier,France,1976
Uses
antihyperlipoproteinemic
Definition
ChEBI: Benzoic acid 2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl ester is a benzoate ester.
Manufacturing Process
To a solution of 24.7 parts of 1-(m-trifluoromethylphenyl)-2-(β-
hydroxyethyl)amino propane in 140 parts of anhydrous benzene, there were
added successively 15 parts of 4.7N hydrochloric ether and a solution of 14
parts of benzoyl chloride in 24 parts of anhydrous benzene. The addition
required 10 minutes, the reaction mixture was then refluxed for 8 hours.
The solid product was collected by filtration and after recrystallization from
230 parts of ethyl acetate, there were obtained 15 parts of 1-(mtrifluoromethylphenyl)-
2-(β-benzoyloxyethyl)amino propane hydrochloride
melting at 161°C.
10 parts hydrochloride are put in suspension in 100 parts of water, 80 parts
ether are added, then 10 parts of a concentrated solution of ammonium
hydroxide. The mixture is stirred a few minutes until the salt is dissolved,
then the ethered solution is poured off and dried. After the ether is
eliminated, 9 parts of 1-(m-trifluoromethylphenyl)-2-(β-
benzoyloxyethyl)amino propane are obtained; the base is a colorless oil.
Therapeutic Function
Antihyperlipidemic, Cardiovascular
BENFLUOREX HYDROCHLORIDESupplier
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- 1-(800)-881-8210
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- 86-21-63210123
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- 021-33632979
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- 400-0066400 13621662912
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- +1-510-219-6317
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