Clobetasone butyrate Chemical Properties

Melting point:

90-100°

Boiling point:

573.3±50.0 °C(Predicted)

Density 

1.1736 (estimate)

storage temp. 

Refrigerator, Under Inert Atmosphere

solubility 

Practically insoluble in water, freely soluble in acetone and in methylene chloride, slightly soluble in ethanol (96 per cent).

form 

Solid

color 

White to Off-White

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents.

InChIKey

FBRAWBYQGRLCEK-JGSYYNBSNA-N

SMILES

[C@]1(C(=O)CCl)(OC(=O)CCC)[C@@H](C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(=O)C[C@]12C |&1:0,11,14,16,26,28,33,r|

CAS DataBase Reference

25122-57-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

40

Safety Statements 

22-36

WGK Germany 

3

RTECS 

TU4154083

HS Code 

29372290

Toxicity

mouse,LD50,intraperitoneal,500mg/kg (500mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 838, 1983.

Clobetasone butyrate Usage And Synthesis

Chemical Properties

White or almost white powder.

Uses

Clobetasone butyrate is a synthetic glucocorticoid which is used as an anti-inflammatory in the treatment of various skin disorders. As a steroid medicine, it can used on the skin to treat swelling, itching and irritation. Such as eczema, including ;contact dermatitis; psoriasis; insect bites and stings; nappy rash.

Definition

ChEBI: Clobetasone butyrate is an organic molecular entity.

Mechanism of action

Topical corticosteroids (Clobetasone butyrate) inhibit the migration of macrophages and leukocytes into areas of inflamed skin by reversing vascular dilation and permeability, resulting in decreased erythema, edema and pruritus.

Side effects

Some people get a burning or stinging feeling for a few minutes when they put clobetasone cream or ointment on their skin. Clobetasone cream contains cetostearyl alcohol and chlorocresol, which may cause local skin reactions or allergic reactions.

Clobetasone butyrate(25122-57-0)Related Product Information

• Tributyrin
• Hexyl butyrate
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• Sodium Butyrate
• Isoamyl butyrate
• Epichlorohydrin
• Chloromethyl butyrate
• Clobetasol propionate
• CHLOROPHOSPHONAZO III
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• 2-FLUOROCYCLOHEXANONE
• 1-Chlorohexadecane
• METHOXYMELONAL
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• Clobetasone
• Chloroacetic acid
• 1-ACETOXY-3-CHLOROACETONE