KRN7000 Chemical Properties

Melting point:

125-130°C

Boiling point:

939.8±65.0 °C(Predicted)

Density 

1.04±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

Pyridine (Slightly, Heated)

form 

White solid.

pka

12.92±0.70(Predicted)

color 

White to Pale Beige

Stability:

Hygroscopic

CAS DataBase Reference

158021-47-7

Safety Information

WGK Germany 

3

HS Code 

2940.00.6000

KRN7000 Usage And Synthesis

Description

KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.

Chemical Properties

White Solid

Uses

KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.

Uses

Galactosylceramides play an important roles in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. It has shown to have significant immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma.

Definition

ChEBI: A glycophytoceramide having an alpha-D-galactosyl residue at the O-1 position and a hexacosanoyl group attached to the nitrogen.

storage

-20°C

References

[1] H. J. J. VAN DER VLIET. Effects of α-galactosylceramide (KRN7000), interleukin-12 and interleukin-7 on phenotype and cytokine profile of human Vα24+ Vβ11+ T cells[J]. Immunology, 2001, 98 4: 557-563. DOI: 10.1046/j.1365-2567.1999.00920.x
[2] NOEMI A. SAAVEDRA-AVILA, AMY R. HOWELL*   A Humanized Mouse Model Coupled with Computational Analysis Identifies Potent Glycolipid Agonist of Invariant NKT Cells[J]. ACS Chemical Biology, 2024, 19 4: 926-937. DOI: 10.1021/acschembio.3c00736
[3] DEYING YANG . Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development[J]. Acta Pharmaceutica Sinica. B, 2022, 12 12: Pages 4432-4445. DOI: 10.1016/j.apsb.2022.05.028

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