KRN7000
KRN7000 Basic information
- Product Name:
- KRN7000
- Synonyms:
-
- (2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol Synonym:α-GalCer or KRN7000
- Α-GALACTOSYLCERAMIDE
- KRN7000
- N-[(1S,2S,3R)-1-[(α-D-Galactopyranosyloxy)Methyl]-2,3-dihydroxyheptadecyl]hexacosanaMide
- α-Galactosyl CeraMide
- α-Galactosyl CeraMide
- Α-GALACTOSYL CERAMIDE
- Α-GALACTOSYL CERAMIDE
- CAS:
- 158021-47-7
- MF:
- C50H99NO9
- MW:
- 858.32
- Product Categories:
-
- Amino Acids & Derivatives
- Protein Kinase Inhibitors and Activators
- Amino Acids 13C, 2H, 15N
- Mol File:
- 158021-47-7.mol
KRN7000 Chemical Properties
- Melting point:
- 125-130°C
- Boiling point:
- 939.8±65.0 °C(Predicted)
- Density
- 1.04±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Pyridine (Slightly, Heated)
- form
- White solid.
- pka
- 12.92±0.70(Predicted)
- color
- White to Pale Beige
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 158021-47-7
KRN7000 Usage And Synthesis
Description
KRN 7000 is a potent synthetic α-
Chemical Properties
White Solid
Uses
KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.
Uses
Galactosylceramides play an important roles in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. It has shown to have significant immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma.
Definition
ChEBI: A glycophytoceramide having an alpha-D-galactosyl residue at the O-1 position and a hexacosanoyl group attached to the nitrogen.
storage
-20°C
KRN7000Supplier
- Tel
- 0512-63001269 15720870325
- sales2@biosyntech-suzhou.com
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 03-36680489
- Sales-JP@TCIchemicals.com
- Tel
- 320-37350700
- sales@tcieurope.eu
KRN7000(158021-47-7)Related Product Information
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- C18 CERAMIDE
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- C14 Dihydroceramide
- DL-ERYTHRO-DIHYDROSPHINGOSINE
- C2 DIHYDROCERAMIDE
- Phytosphingosine
- C14 CERAMIDE
- KRN7000
- C22 Dihydroceramide
- C22 Ceramide
- N-PALMITOYL SERINOL
- DL-1,3-DIHYDROXY-2-AMINO-OCTADECANE
- N-(2-HYDROXY-1R-METHYLETHYL)-HEXADECANAMIDE
- N-(2R-HYDROXYPROPYL)-HEXADECANAMIDE
- C18 Dihydroceramide
- C4 Dihydroceramide
- N-LIGNOCEROYL-DL-DIHYDROSPHINGOSINE