Basic information Safety Supplier Related

KRN7000

Basic information Safety Supplier Related

KRN7000 Basic information

Product Name:
KRN7000
Synonyms:
  • (2S,3S,4R)-1-O-(α-D-Galactopyranosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol Synonym:α-GalCer or KRN7000
  • Α-GALACTOSYLCERAMIDE
  • KRN7000
  • N-[(1S,2S,3R)-1-[(α-D-Galactopyranosyloxy)Methyl]-2,3-dihydroxyheptadecyl]hexacosanaMide
  • α-Galactosyl CeraMide
  • α-Galactosyl CeraMide
  • Α-GALACTOSYL CERAMIDE
  • Α-GALACTOSYL CERAMIDE
CAS:
158021-47-7
MF:
C50H99NO9
MW:
858.32
Product Categories:
  • Amino Acids & Derivatives
  • Protein Kinase Inhibitors and Activators
  • Amino Acids 13C, 2H, 15N
Mol File:
158021-47-7.mol
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KRN7000 Chemical Properties

Melting point:
125-130°C
Boiling point:
939.8±65.0 °C(Predicted)
Density 
1.04±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Pyridine (Slightly, Heated)
form 
White solid.
pka
12.92±0.70(Predicted)
color 
White to Pale Beige
Stability:
Hygroscopic
CAS DataBase Reference
158021-47-7
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Safety Information

WGK Germany 
3
HS Code 
2940.00.6000
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KRN7000 Usage And Synthesis

Description

KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.

Chemical Properties

White Solid

Uses

KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.

Uses

Galactosylceramides play an important roles in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. It has shown to have significant immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma.

Definition

ChEBI: A glycophytoceramide having an alpha-D-galactosyl residue at the O-1 position and a hexacosanoyl group attached to the nitrogen.

storage

-20°C

KRN7000Supplier

Suzhou Biosyntech Co., Ltd. Gold
Tel
0512-63001269 15720870325
Email
sales2@biosyntech-suzhou.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Email
Sales-JP@TCIchemicals.com
TCI Europe
Tel
320-37350700
Email
sales@tcieurope.eu