SALVINORIN A Chemical Properties

Melting point:

238-240° (Ortega); mp 242-244° (Valdes, 1984)

alpha 

D22 -45.3° (c = 8.530 in CHCl3); D25 -41° (c = 1 in CHCl3)

Boiling point:

563.8±50.0 °C(Predicted)

Density 

1.28±0.1 g/cm3(Predicted)

Flash point:

2℃

storage temp. 

−20°C

solubility 

DMSO: ≥10mg/mL

form 

powder

color 

white

Safety Information

Hazard Codes 

F,Xn

Risk Statements 

11-20/21/22-36

Safety Statements 

22-24/25-36/37-16

RIDADR 

UN 1648 3 / PGII

WGK Germany 

3

RTECS 

QL6127142

Hazardous Substances Data

83729-01-5(Hazardous Substances Data)

SALVINORIN A Usage And Synthesis

Description

Salvinorin A (Item No. 11487) is an analytical reference material categorized as a diterpene. It is a hallucinogen derived from S. divinorum that has been used in the traditional spiritual practices of the Mazatec Indians and as a recreational drug. This product is intended for research and forensic applications.

Uses

Salvinorin A is a potent and selective kappa-opioid receptor agonist. Salvinorin A has been reported to be brain-penetrant and displays psychoactive properties; hallucinogen.

Uses

Salvinorin A is a hallucinogenic derived from the S. divinorum plant used in traditional spiritual practices of the Mazatec Indians and now gaining popularity as a recreational drug. Unlike other hallucinogens, which mediate their effects through serotonin 5-HT2A receptors, salvinorin A is a potent, selective κ-opioid receptor agonist (Ki = 2.4 nM; EC50 = 1.8 nM). This product is intended for forensic and research applications.In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions.

Uses

In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions.

Definition

ChEBI: A natural product found in Salvia divinorum.

Biological Activity

Potent naturally occuring non-nitrogenous κ -opioid selective agonist that displays high affinity at both native (K i = 4.3 nM) and cloned (K i = 16 nM) κ -opioid receptors. Also exhibits allosteric modulation of μ -opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties.

Biochem/physiol Actions

Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (Ki=4.3 nm) and cloned (Ki=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor.

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