DIMT1 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

Dimethyladenosine transferase 1, also known as DIMT1L, is a methyltransferase responsible for the dimethylation of adenosines on the 18S rRNA subunit. Binding of DIMT1 to the pre-rRNA is required for proper processing of the 18S subunit. Independent of its catalytic activity, DIMT1 seems to function as a scaffold protein that is essential for the assembly of the 40S rRNA subunit. DIMT1 also has been shown to have higher expression in certain cancer types, including multiple myeloma and gastric cancer.

References

[1] Zorbas, C. et al. (2015) Mol Biol Cell 26, 2080-95.
[2] Shen, H. et al. (2020) J Biol Chem 295, 12058-12070.
[3] Ikeda, S. et al. (2017) Cancer Sci 108, 641-652.
[4] Liu, G. et al. (2017) Hum Pathol 70, 35-42.

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