NME1 antibody Usage And Synthesis

Applications

NME1 antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity.

Immunogen

Anti-human NME1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NME1 amino acids 1-152 purified from E. coli.

Background

NDK (Nucleoside diphosphate kinase) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by NME2) isoforms. NME1 is involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. It also has tumor metastasis-suppressive capacity. NME1 has a key role in the synthesis of nucleoside triphosphates other than ATP. NME1 is essential for neural development including neural patterning and cell future determination. 
The NME1 gene is expressed in various tumor types where its levels have been alternatively linked to reduced or increased metastatic potential. 
Decrease in NME1 expression is notably connected to aggressive behavior in melanoma, breast, colon, and gastric carcinomas. In contrast, elevated levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas.
Somatic mutations of the NME1 gene are found in neuroblastoma. Increased NME1 in neuroblastoma is linked to features of the disease that are associated with aggressive tumors.

NME1 antibody()Related Product Information

• AK1 antibody
• ADAM21 antibody
• PTPRA antibody
• Mouse Monoclonal PTPN14 Antibody
• RNase T2 antibody
• Mouse Monoclonal GRM2 Antibody
• KRT81 antibody
• STAT 5 antibody
• FXYD1 antibody
• ANGPTL7 Antibody