VAV1 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Mouse;Rat;Human

Background

Vav proteins belong to the Dbl family of guanine nucleotide exchange factors for Rho/Rac small GTPases. The three identified mammalian Vav proteins differ in their expression. Vav1 is expressed only in hematopoietic cells and is involved in the formation of the immune synapse. Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain the Dbl homology domain, which confers GEF activity, as well as protein interaction domains that allow them to function in pathways regulating actin cytoskeleton organization. Phosphorylation stimulates the GEF activity of Vav protein towards Rho/Rac.

References

[1] Hornstein, I. et al. (2004) Cell. Signal. 16, 1-11.
[2] Crespo, P. et al. (1997) Nature 385, 169-172.
[3] Han, J. et al. (1997) Mol. Cell. Biol. 17, 1346-1353.

VAV1 antibody()Related Product Information

• VASH2 Antibody
• VASH1 antibody
• VARS antibody
• VAT1 antibody
• VAV3 antibody
• VAV2 antibody
• ANTI-VASP
• VAT1L Antibody
• VHL Antibody
• VBP1 ANTIBODY