NSC745887 Chemical Properties

Melting point:

241-242 °C(Solv: dichloromethane (75-09-2))

Boiling point:

491.6±40.0 °C(Predicted)

Density 

1.448±0.06 g/cm3(Predicted)

pka

-2.36±0.20(Predicted)

NSC745887 Usage And Synthesis

Uses

NSC745887 (compound 25) is an inhibitor that targets DNA topoisomerase cleavage, activates the caspase-8/9-caspase-3-poly (ADP-ribose) polymerase cascade, and induces apoptosis in cancer cells. NSC745887 enhances γH2AX expression and causes DNA fragmentation leading to DNA damage[1][2].

References

[1] Fann LY, et al. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget. 2017 Dec 27;9(15):11922-11937. DOI:10.18632/oncotarget.23714
[2] Huang HS, et al. Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues. Bioorg Med Chem. 2009;17(21):7418-7428. DOI:10.1016/j.bmc.2009.09.033

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